| movie | Ballad of a Small Player (2025)As Cynthia Blithe | (Not seen) |
| tv | Fantasmas (2024)As Water (voice)(1 episode) | (Not seen) |
| movie | The Room Next Door (2024)As Martha | (Not seen) |
| movie | The Killer (2023)As The Expert | (Not seen) |
| movie | Asteroid City (2023)As Dr. Hickenlooper | (Not seen) |
| movie | Guillermo del Toro's Pinocchio (2022)As (voice) | (Not seen) |
| movie | Three Thousand Years of Longing (2022)As Alithea Binnie | (Not seen) |
| tv | Marvel Studios Legends (2021)As The Ancient One (archive footage) (uncredited)(1 episode) | (Not seen) |
| tv | What If...? (2021)As The Ancient One (voice)(1 episode) | (Not seen) |
| movie | The French Dispatch (2021) (AKA "The French Dispatch of the Liberty, Kansas Evening Sun")As J. K. L. Berensen | (Not seen) |
| movie | Last and First Men (2020)As Narrator (voice) | (Not seen) |
| tv | What We Do in the Shadows (2019)As Tilda(1 episode) | (Not seen) |
| tv | The Boys (2019)As Ambrosius (voice)(3 episodes) | (Not seen) |
| movie | The Personal History of David Copperfield (2019)As Betsey Trotwood | (Not seen) |
| movie | The Dead Don't Die (2019)As Zelda Winston | (Not seen) |
| movie | Uncut Gems (2019)As Anna (voice) | (Not seen) |
| movie | Avengers: Endgame (2019)As The Ancient One | (Not seen) |
| movie | Suspiria (2018)As Madame Blanc / Dr. Klemperer / Helena Markos | (Not seen) |
| movie | Isle of Dogs (2018)As Oracle (voice) | (Not seen) |
| movie | Okja (2017)As Lucy Mirando / Nancy Mirando | (Not seen) |
| movie | War Machine (2017)As German Politician | (Not seen) |
| movie | Doctor Strange (2016)As The Ancient One | (Not seen) |
| movie | Hail, Caesar! (2016) (AKA "Hail, Caesar! A Tale of The Christ")As Thora Thacker / Thessaly Thacker | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self(1 episode) | (Not seen) |
| movie | A Bigger Splash (2015)As Marianne Lane | (Not seen) |
| movie | Trainwreck (2015)As Dianna | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(2 episodes) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self - Guest(1 episode) | (Not seen) |
| movie | The Grand Budapest Hotel (2014)As Madame Céline Villeneuve Desgoffe-und-Taxis | (Not seen) |
| movie | Only Lovers Left Alive (2013)As Eve | (Not seen) |
| movie | The Zero Theorem (2013)As Dr. Shrink-Rom | (Not seen) |
| movie | Snowpiercer (2013)As Minister Mason | (Not seen) |
| movie | Moonrise Kingdom (2012)As Social Services | (Not seen) |
| movie | We Need to Talk About Kevin (2011)As Eva Khatchadourian | (Not seen) |
| movie | The Chronicles of Narnia: The Voyage of the Dawn Treader (2010)As The White Witch | (Not seen) |
| movie | I Am Love (2009) (AKA "Io sono l'amore")As Emma Recchi | (Not seen) |
| movie | The Limits of Control (2009) (AKA "No Limtis No Control")As Blonde | (Not seen) |
| movie | The Curious Case of Benjamin Button (2008)As Elizabeth Abbott | (Not seen) |
| movie | Burn After Reading (2008)As Katie Cox | (Not seen) |
| movie | The Chronicles of Narnia: Prince Caspian (2008) (AKA "Prince Caspian")As White Witch | (Not seen) |
| movie | Michael Clayton (2007)As Karen Crowder | (Not seen) |
| movie | Broken Flowers (2005)As Penny | (Not seen) |
| movie | Thumbsucker (2005)As Audrey Cobb | (Not seen) |
| movie | The Chronicles of Narnia: The Lion, the Witch and the Wardrobe (2005) (AKA "The Chronicles of Narnia")As White Witch | (Not seen) |
| movie | Constantine (2005)As Gabriel | (Not seen) |
| movie | Young Adam (2003)As Ella Gault | (Not seen) |
| movie | Adaptation. (2002) (AKA "The Orchid Thief")As Valerie Thomas | (Not seen) |
| movie | The Deep End (2001)As Margaret Hall | (Not seen) |
| movie | Vanilla Sky (2001)As Rebecca Dearborn | (Not seen) |
| movie | Possible Worlds (2000)As Joyce | (Not seen) |
| movie | The Beach (2000)As Sal | (Not seen) |
| movie | The Protagonists (1999)As Actress | (Not seen) |
| tv | The Daily Show (1996)As Self(1 episode) | (Not seen) |
| movie | Wittgenstein (1993)As Lady Ottoline Morrell | (Not seen) |
| movie | Orlando (1992)As Orlando | (Not seen) |
| movie | The Garden (1990)As Madonna/Voice Overs | (Not seen) |
| movie | War Requiem (1989)As The Nurse | (Not seen) |
| movie | The Last of England (1987)As The Maid | (Not seen) |
| movie | Caravaggio (1986)As Lena | (Not seen) |
| tv | The Oscars (1953)As Self(1 episode) | (Not seen) |