| tv | Number One on the Call Sheet (2025)As Self(1 episode) | (Not seen) |
| movie | SNL50: The Homecoming Concert (2025) | (Not seen) |
| tv | Lady in the Lake (2024)As Woman at Funeral (uncredited) | (Not seen) |
| movie | Babes (2024)As Dawn's Breasts | (Not seen) |
| movie | Super/Man: The Christopher Reeve Story (2024)As Self | (Not seen) |
| movie | Ezra (2023)As Jayne | (Not seen) |
| movie | The Color Purple (2023)As Midwife (uncredited) | (Not seen) |
| movie | My Father's Dragon (2022)As Cat (voice) | (Not seen) |
| movie | Luck (2022)As Captain (voice) | (Not seen) |
| movie | Till (2022)As Alma | (Not seen) |
| tv | Marvel's M.O.D.O.K. (2021)As Marian Pouncy / Poundcakes (voice)(1 episode) | (Not seen) |
| tv | JFK: Destiny Betrayed (2021)As Self - Narrator (voice)(4 episodes) | (Not seen) |
| tv | Hacks (2021)As Whoopi Goldberg(1 episode) | (Not seen) |
| movie | JFK Revisited: Through the Looking Glass (2021)As Narrator (voice) | (Not seen) |
| tv | Two Weeks to Live (2020)As Vashti Blue | (Not seen) |
| tv | Star Trek: Picard (2020)As Guinan(2 episodes) | (Not seen) |
| tv | The Stand (2020)As Abagail "Mother Abagail" Freemantle(9 episodes) | (Not seen) |
| movie | Miss Americana (2020) | (Not seen) |
| tv | Lorena (2019)As Herself(1 episode) | (Not seen) |
| tv | Godfather of Harlem (2019)As Miss Willa(5 episodes) | (Not seen) |
| movie | I Am Mother (2019)As Self (archive footage) (uncredited) | (Not seen) |
| tv | James Cameron's Story of Science Fiction (2018)As Self(2 episodes) | (Not seen) |
| movie | Robin Williams: Come Inside My Mind (2018) | (Not seen) |
| movie | Vice (2018)As Self (archive footage) | (Not seen) |
| movie | Decorating Disney: Holiday Magic (2017)As Host | (Not seen) |
| movie | Spielberg (2017) | (Not seen) |
| tv | The Tick (2016)As Whoopi Goldberg(1 episode) | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self - Guest(2 episodes) | (Not seen) |
| tv | Broad City (2014)As Self(1 episode) | (Not seen) |
| tv | BoJack Horseman (2014)As Mikhaela (voice)(1 episode) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(7 episodes) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self(5 episodes) | (Not seen) |
| movie | Top Five (2014)As Self | (Not seen) |
| movie | Teenage Mutant Ninja Turtles (2014)As Bernadette Thompson | (Not seen) |
| movie | Blackfish (2013)As Self | (Not seen) |
| movie | Katy Perry: Part of Me (2012)As Self | (Not seen) |
| movie | A Little Bit of Heaven (2011)As God | (Not seen) |
| movie | The Muppets (2011)As Self | (Not seen) |
| movie | Toy Story 3 (2010) (AKA "3")As Stretch (voice) | (Not seen) |
| tv | RuPaul's Drag Race (2009)As Self - Guest Judge(2 episodes) | (Not seen) |
| tv | The Middle (2009)As Jane Marsh(1 episode) | (Not seen) |
| tv | Glee (2009)As Carmen Tibideaux(6 episodes) | (Not seen) |
| movie | Madea Goes to Jail (2009) (AKA "Tyler Perry's Madea Goes to Jail")As Whoopi | (Not seen) |
| movie | Snow Buddies (2008)As Miss Mittens (voice) | (Not seen) |
| movie | A Muppets Christmas: Letters to Santa (2008)As Taxi Driver | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(2 episodes) | (Not seen) |
| tv | 30 Rock (2006)As Whoopi Goldberg(2 episodes) | (Not seen) |
| movie | Everyone's Hero (2006)As Darlin' (voice) | (Not seen) |
| movie | Doogal (2006)As Ermintrude (voice) | (Not seen) |
| tv | Hell's Kitchen (2005)As Self - Restaurant Patron(2 episodes) | (Not seen) |
| movie | The Pacifier (2005) (AKA "Gnome") | (Not seen) |
| tv | Entourage (2004)As Whoopi Goldberg(1 episode) | (Not seen) |
| movie | The Lion King 1½ (2004)As Shenzi (voice) | (Not seen) |
| movie | Superbabies: Baby Geniuses 2 (2004)As Whoopi Goldberg | (Not seen) |
| tv | Real Time with Bill Maher (2003)As Self(2 episodes) | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(2 episodes) | (Not seen) |
| movie | Pauly Shore Is Dead (2003)As Whoopi Goldberg | (Not seen) |
| movie | It's a Very Merry Muppet Christmas Movie (2002)As Daniel's 'Boss' | (Not seen) |
| movie | Star Trek: Nemesis (2002)As Guinan | (Not seen) |
| movie | Monkeybone (2001)As Death | (Not seen) |
| movie | Rat Race (2001)As Vera Baker | (Not seen) |
| movie | The Adventures of Rocky & Bullwinkle (2000)As Judge Cameo | (Not seen) |
| tv | Law & Order: Special Victims Unit (1999)As Janette Grayson(1 episode) | (Not seen) |
| movie | Alice in Wonderland (1999)As Cheshire Cat | (Not seen) |
| movie | The Deep End of the Ocean (1999)As Candy Bliss | (Not seen) |
| movie | Girl, Interrupted (1999)As Valerie Owens | (Not seen) |
| tv | Whose Line Is It Anyway? (1998)As Self(2 episodes) | (Not seen) |
| movie | A Knight in Camelot (1998)As Dr. Vivien Morgan | (Not seen) |
| movie | The Rugrats Movie (1998)As Ranger Margaret (voice) | (Not seen) |
| movie | In & Out (1997)As Whoopi Goldberg (uncredited) | (Not seen) |
| movie | Bogus (1996)As Harriet Franklin | (Not seen) |
| movie | Ghosts of Mississippi (1996) (AKA "Ghosts from the Past")As Myrlie Evers | (Not seen) |
| movie | Bordello of Blood (1996) (AKA "Dead Easy")As Hospital Patient (uncredited) | (Not seen) |
| movie | Eddie (1996)As Eddie Franklin | (Not seen) |
| movie | The Celluloid Closet (1995)As Self | (Not seen) |
| movie | Theodore Rex (1995)As Katie Coltrane | (Not seen) |
| movie | Boys on the Side (1995)As Jane Deluca | (Not seen) |
| movie | Corrina, Corrina (1994)As Corrina Washington | (Not seen) |
| movie | The Pagemaster (1994)As Fantasy (voice) | (Not seen) |
| movie | The Little Rascals (1994)As Buckwheat's Mom | (Not seen) |
| movie | The Lion King (1994) (AKA "The Lion King 3D")As Shenzi the Hyena (voice) | (Not seen) |
| movie | Star Trek: Generations (1994) (AKA "Star Trek 7")As Guinan | (Not seen) |
| tv | The Nanny (1993)As Whoopi Goldberg(2 episodes) | (Not seen) |
| movie | Made in America (1993)As Sarah Mathews | (Not seen) |
| movie | Sister Act 2: Back in the Habit (1993)As Deloris Van Cartier | (Not seen) |
| movie | Loaded Weapon 1 (1993) (AKA "National Lampoon's Loaded Weapon 1")As Billy York | (Not seen) |
| movie | Sarafina! (1992)As Mary Masembuko | (Not seen) |
| movie | The Player (1992)As Susan Avery | (Not seen) |
| movie | Sister Act (1992)As Deloris Van Cartier/Sister Mary Clarence | (Not seen) |
| movie | Soapdish (1991)As Rose Schwartz | (Not seen) |
| movie | House Party 2 (1991)As Professor | (Not seen) |
| movie | Ghost (1990)As Oda Mae Brown | (Not seen) |
| movie | Homer and Eddie (1989)As Eddie Cervi | (Not seen) |
| movie | Christmas at Pee-wee's Playhouse (1988) (AKA "Pee-wee's Playhouse Christmas Special")As Self | (Not seen) |
| movie | Burglar (1987)As Bernice 'Bernie' Rhodenbarr | (Not seen) |
| movie | Fatal Beauty (1987)As Rita Rizzoli | (Not seen) |
| movie | Jumpin' Jack Flash (1986) (AKA "Knock, Knock")As Terry Dolittle | (Not seen) |
| movie | The Color Purple (1985)As Celie Harris Johnson | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Cameo (uncredited)(2 episodes) | (Not seen) |
| tv | The Oscars (1953)As Self(8 episodes) | (Not seen) |