| movie | Avengers: Doomsday (2026)As Dr. Henry 'Hank' McCoy / Beast | (Not seen) |
| movie | The Most Wonderful Time of the Year (2024)As Sideshow Bob (voice) | (Not seen) |
| movie | Jesus Revolution (2023)As Chuck Smith | (Not seen) |
| movie | The Marvels (2023)As Dr. Henry 'Hank' McCoy / Beast | (Not seen) |
| tv | Dr. Death (2021)As Dr. Geoffrey Skadden (voice)(4 episodes) | (Not seen) |
| movie | Father Christmas Is Back (2021)As James Christmas | (Not seen) |
| movie | Charming the Hearts of Men (2021)As The Congressman | (Not seen) |
| movie | Miss Willoughby (2021) (AKA "Miss Willoughby and the Haunted Bookshop")As Robert Thompson | (Not seen) |
| movie | The God Committee (2021)As Dr. Andre Boxer | (Not seen) |
| tv | Proven Innocent (2019)As Gore Bellows(13 episodes) | (Not seen) |
| movie | Grand Isle (2019)As Detective Jones | (Not seen) |
| movie | Storks (2016)As Hunter (voice) | (Not seen) |
| movie | Neighbors 2: Sorority Rising (2016) (AKA "Bad Neighbours 2")As Shelby's Dad | (Not seen) |
| tv | Unbreakable Kimmy Schmidt (2015)As Kelsey Grammer (voice)(1 episode) | (Not seen) |
| movie | Mariah Carey's Merriest Christmas (2015)As Self | (Not seen) |
| movie | Best of Enemies: Buckley vs. Vidal (2015) (AKA "Best of Enemies")As Voice of William F. Buckley | (Not seen) |
| movie | Entourage (2015)As Kelsey Grammer | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(1 episode) | (Not seen) |
| movie | Reach Me (2014)As Angelo Aldo Brandini | (Not seen) |
| movie | Transformers: Age of Extinction (2014) (AKA "Transformers 4")As Harold Attinger | (Not seen) |
| movie | The Expendables 3 (2014)As Bonaparte | (Not seen) |
| movie | X-Men: Days of Future Past (2014) (AKA "X-Men: First Class 2")As Hank McCoy / Beast (older) | (Not seen) |
| movie | I Don't Know How She Does It (2011)As Clark Cooper | (Not seen) |
| movie | Crazy on the Outside (2010)As Frank | (Not seen) |
| tv | Modern Family (2009)As Keifth(1 episode) | (Not seen) |
| movie | Middle Men (2009)As Frank Griffin | (Not seen) |
| movie | Fame (2009)As Mr. Martin Cranston | (Not seen) |
| movie | An American Carol (2008) (AKA "Big Fat Important Movie")As General George S. Patton | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(1 episode) | (Not seen) |
| tv | 30 Rock (2006)As Kelsey Grammer(3 episodes) | (Not seen) |
| movie | Even Money (2006) (AKA "Jump Shot")As Detective Brunner | (Not seen) |
| movie | X-Men: The Last Stand (2006) (AKA "X-Men 3")As Dr. Henry "Hank" McCoy / Beast | (Not seen) |
| tv | Project Runway (2004)As Self(1 episode) | (Not seen) |
| movie | Teacher's Pet (2004) (AKA "Disney's Teacher's Pet")As Dr. Ivan Krank (voice) | (Not seen) |
| tv | Peep Show (2003)As Snowball (voice) | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(2 episodes) | (Not seen) |
| movie | Barbie of Swan Lake (2003)As Rothbart (voice) | (Not seen) |
| movie | Just Visiting (2001) (AKA "My Lovely Fiancee")As Narrator | (Not seen) |
| movie | 15 Minutes (2001)As Robert Hawkins | (Not seen) |
| movie | Mickey's Once Upon a Christmas (1999)As Narrator (voice) | (Not seen) |
| movie | Toy Story 2 (1999)As Stinky Pete the Prospector (voice) | (Not seen) |
| movie | The Pentagon Wars (1998)As Maj. Gen. Partridge | (Not seen) |
| movie | Anastasia (1997)As Vladimir (voice) | (Not seen) |
| tv | The Daily Show (1996)As Self(1 episode) | (Not seen) |
| movie | Down Periscope (1996)As Lt. Commander Thomas "Tom" Dodge | (Not seen) |
| tv | Frasier (1993)As Frasier Crane(264 episodes) | (Not seen) |
| tv | The Simpsons (1989)As Sideshow Bob (voice)(25 episodes) | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Host(3 episodes) | (Not seen) |