| movie | Avengers: Secret Wars (2027)As Valentina Allegra de Fontaine | (Not seen) |
| movie | The Sheep Detectives (2026)As Lily (voice) | (Not seen) |
| tv | SNL50: Beyond Saturday Night (2025)As Self(1 episode) | (Not seen) |
| movie | SNL50: The Homecoming Concert (2025)As Self | (Not seen) |
| movie | Thunderbolts* (2025)As Valentina Allegra de Fontaine | (Not seen) |
| movie | You Hurt My Feelings (2023)As Beth | (Not seen) |
| movie | You People (2023)As Shelley | (Not seen) |
| movie | Black Panther: Wakanda Forever (2022)As Valentina Allegra de Fontaine | (Not seen) |
| tv | Marvel Studios Assembled (2021)As Self - Valentina Allegra de Fontaine(1 episode) | (Not seen) |
| tv | The Falcon and the Winter Soldier (2021)As Val(2 episodes) | (Not seen) |
| movie | Black Widow (2021)As Contessa Valentina Allegra de Fontaine (uncredited) | (Not seen) |
| movie | Onward (2020)As Laurel Lightfoot (voice) | (Not seen) |
| movie | Downhill (2020)As Billie | (Not seen) |
| tv | My Next Guest Needs No Introduction with David Letterman (2018)As Self(1 episode) | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self - Guest(4 episodes) | (Not seen) |
| tv | Hot Ones (2015)As Self(1 episode) | (Not seen) |
| tv | Last Week Tonight with John Oliver (2014)As Self(1 episode) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(1 episode) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(1 episode) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self(2 episodes) | (Not seen) |
| movie | Planes (2013)As Rochelle (voice) | (Not seen) |
| movie | Enough Said (2013)As Eva | (Not seen) |
| tv | Veep (2012)As Selina Meyer(65 episodes) | (Not seen) |
| tv | Comedians in Cars Getting Coffee (2012)As Self(1 episode) | (Not seen) |
| movie | The Pixar Story (2007)As Atta (voice) (archive footage) | (Not seen) |
| tv | 30 Rock (2006)As Liz Lemon(1 episode) | (Not seen) |
| movie | Saturday Night Live in the '80s: Lost & Found (2005) (AKA "Saturday Night Live in the '80s: Lost and Found")As Self | (Not seen) |
| tv | Peep Show (2003)As Mollie (voice) | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(3 episodes) | (Not seen) |
| tv | Arrested Development (2003)As Maggie Lizer(4 episodes) | (Not seen) |
| movie | Naqoyqatsi (2002) (AKA "Naqoyqatsi: Life as War")As Self (archive footage) (uncredited) | (Not seen) |
| tv | Curb Your Enthusiasm (2000)As Julia Louis-Dreyfus(8 episodes) | (Not seen) |
| movie | A Bug's Life (1998) (AKA "Bugs")As Atta (voice) | (Not seen) |
| movie | Deconstructing Harry (1997) (AKA "The Meanest Man in the World")As Leslie | (Not seen) |
| movie | Fathers' Day (1997)As Carrie Lawrence | (Not seen) |
| tv | The Daily Show (1996)As Self(3 episodes) | (Not seen) |
| tv | Hey Arnold! (1996)As Miss Felter (voice)(1 episode) | (Not seen) |
| movie | North (1994)As North's Mom | (Not seen) |
| tv | Dinosaurs (1991)As Heather Worthington (voice)(1 episode) | (Not seen) |
| tv | The Simpsons (1989)As Gloria (voice)(3 episodes) | (Not seen) |
| tv | Seinfeld (1989)As Elaine Benes(180 episodes) | (Not seen) |
| movie | National Lampoon's Christmas Vacation (1989)As Margo Chester | (Not seen) |
| movie | Troll (1986)As Jeanette Cooper | (Not seen) |
| movie | Soul Man (1986) (AKA "The Imposter")As Lisa Stimson | (Not seen) |
| movie | Hannah and Her Sisters (1986)As Mary | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Various Characters(60 episodes) | (Not seen) |
| tv | The Oscars (1953)As Self(2 episodes) | (Not seen) |