| movie | SNL50: The Homecoming Concert (2025) | (Not seen) |
| movie | The Guardians of the Galaxy Holiday Special (2022)As Kyra Sedgwick (voice) | (Not seen) |
| movie | Villains (2019)As Gloria | (Not seen) |
| tv | Full Frontal with Samantha Bee (2016)As Self(1 episode) | (Not seen) |
| tv | Chelsea (2016)As Self(1 episode) | (Not seen) |
| movie | The Edge of Seventeen (2016) (AKA "Sweet 17 Monster")As Mona Franklin | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self - Guest(1 episode) | (Not seen) |
| movie | Cop Car (2015)As Dispatch | (Not seen) |
| movie | Time Out of Mind (2014)As Karen / Fake Sheila | (Not seen) |
| movie | Reach Me (2014)As Colette | (Not seen) |
| tv | Brooklyn Nine-Nine (2013)As Madeline Wuntch(12 episodes) | (Not seen) |
| movie | Kill Your Darlings (2013)As Marian Carr (uncredited) | (Not seen) |
| movie | The Possession (2012)As Stephanie | (Not seen) |
| movie | Man on a Ledge (2012)As Suzie Morales | (Not seen) |
| tv | RuPaul's Drag Race (2009)As Self - Guest Judge(1 episode) | (Not seen) |
| movie | Gamer (2009)As Gina Parker Smith | (Not seen) |
| movie | Justice League: The New Frontier (2008)As Lois Lane (voice) | (Not seen) |
| movie | The Game Plan (2007)As Stella Peck | (Not seen) |
| movie | Loverboy (2005)As Emily | (Not seen) |
| movie | The Woodsman (2004)As Vicki | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(1 episode) | (Not seen) |
| movie | Batman: Mystery of the Batwoman (2003)As Batwoman | (Not seen) |
| movie | Secondhand Lions (2003)As Mae | (Not seen) |
| movie | Personal Velocity (2002) (AKA "Enter Fleeing")As Delia Shunt | (Not seen) |
| movie | Montana (1998) (AKA "Nothing Personal")As Claire Kelsky | (Not seen) |
| movie | Phenomenon (1996)As Lace Pennamin | (Not seen) |
| movie | Murder in the First (1995)As Blanche | (Not seen) |
| movie | Heart and Souls (1993)As Julia | (Not seen) |
| movie | Singles (1992)As Linda Powell | (Not seen) |
| movie | Born on the Fourth of July (1989)As Donna | (Not seen) |
| tv | Miami Vice (1984)As Sarah MacPhail(1 episode) | (Not seen) |