| tv | The Studio (2025)As Maya Mason(10 episodes) | (Not seen) |
| movie | Fixed (2025)As Honey (voice) | (Not seen) |
| tv | Hot Ones Versus (2024)As Self(1 episode) | (Not seen) |
| tv | Agatha All Along (2024)As Agnes O'Connor / Agatha Harkness(9 episodes) | (Not seen) |
| movie | Spider-Man: Across the Spider-Verse (2023)As Doc Ock (voice) | (Not seen) |
| movie | Hotel Transylvania 4: Transformania (2022) (AKA "Hotel Transylvania: Transformania")As Ericka (voice) | (Not seen) |
| movie | Glass Onion (2022) (AKA "Glass Onion: A Knives Out Mystery")As Claire Debella | (Not seen) |
| tv | The Shrink Next Door (2021)As Phyllis Shapiro(8 episodes) | (Not seen) |
| tv | Marvel Studios Legends (2021)As Agnes / Agatha Harkness (archive footage) (uncredited)(1 episode) | (Not seen) |
| tv | Marvel Studios Assembled (2021)As Self - Agnes(1 episode) | (Not seen) |
| tv | WandaVision (2021)As Agnes / Agatha Harkness(9 episodes) | (Not seen) |
| tv | What If...? (2021)As Agatha Harkness (voice)(1 episode) | (Not seen) |
| movie | Marvel Studios' 2021 Disney+ Day Special (2021)As Agnes / Agatha Harkness (archive footage) | (Not seen) |
| tv | I Know This Much Is True (2020)As Dessa Constantine(6 episodes) | (Not seen) |
| tv | Die Hart (2020)As Jillian Avery(7 episodes) | (Not seen) |
| tv | Central Park (2020)As Paige (voice)(39 episodes) | (Not seen) |
| movie | Marvel Studios: Expanding the Universe (2019)As Self | (Not seen) |
| movie | Private Life (2018)As Rachel Biegler | (Not seen) |
| movie | Spider-Man: Into the Spider-Verse (2018)As Olivia 'Liv' Octavius / Doc Ock (voice) | (Not seen) |
| movie | Hotel Transylvania 3: Summer Vacation (2018)As Ericka Van Helsing (voice) | (Not seen) |
| movie | A Bad Moms Christmas (2017)As Carla Dunkler | (Not seen) |
| tv | Angie Tribeca (2016)As Susan(1 episode) | (Not seen) |
| movie | Bad Moms (2016)As Carla Dunkler | (Not seen) |
| movie | The Do-Over (2016)As Becca | (Not seen) |
| movie | Captain Fantastic (2016)As Harper | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self(1 episode) | (Not seen) |
| movie | The Family Fang (2015)As Young Camille | (Not seen) |
| movie | The Visit (2015)As Mother | (Not seen) |
| movie | The D Train (2015)As Stacey Landsman | (Not seen) |
| movie | Tomorrowland (2015)As Ursula | (Not seen) |
| tv | Transparent (2014)As Raquel Fein(22 episodes) | (Not seen) |
| tv | Last Week Tonight with John Oliver (2014)As Wife(1 episode) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self - Guest(3 episodes) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(2 episodes) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self - Guest(5 episodes) | (Not seen) |
| movie | She's Funny That Way (2014) (AKA "My Funny Lady")As Delta Simmons | (Not seen) |
| movie | This Is Where I Leave You (2014)As Annie Altman | (Not seen) |
| tv | Kroll Show (2013)As Mikey's Mom(4 episodes) | (Not seen) |
| tv | Brooklyn Nine-Nine (2013)As Eleanor(1 episode) | (Not seen) |
| movie | Bad Words (2013)As Jenny Widgeon | (Not seen) |
| movie | The Secret Life of Walter Mitty (2013)As Odessa Mitty | (Not seen) |
| movie | We're the Millers (2013)As Edie Fitzgerald | (Not seen) |
| tv | The Newsroom (2012)As Carrie(1 episode) | (Not seen) |
| tv | Girls (2012)As Katherine Lavoyt(4 episodes) | (Not seen) |
| movie | Wanderlust (2012)As Karen | (Not seen) |
| movie | The Dictator (2012)As Pregnant Woman | (Not seen) |
| tv | NTSF:SD:SUV:: (2011)As Marge(1 episode) | (Not seen) |
| tv | Bob's Burgers (2011)As Jessica (voice)(3 episodes) | (Not seen) |
| movie | Our Idiot Brother (2011) (AKA "My Idiot Brother")As Janet Ziebell | (Not seen) |
| movie | How Do You Know (2010)As Annie | (Not seen) |
| tv | Parks and Recreation (2009)As Jennifer Barkley(10 episodes) | (Not seen) |
| movie | The Goods: Live Hard, Sell Hard (2009)As Babs Merrick | (Not seen) |
| tv | Childrens Hospital (2008)As Lamaze Teacher(1 episode) | (Not seen) |
| movie | Revolutionary Road (2008)As Milly Campbell | (Not seen) |
| movie | Step Brothers (2008)As Alice | (Not seen) |
| movie | The Last Mimzy (2007)As Naomi Schwartz | (Not seen) |
| movie | The Holiday (2006)As Bristol | (Not seen) |
| tv | Robot Chicken (2005)As Mrs. Marquez / T-Shirt Girl #1 (voice)(1 episode) | (Not seen) |
| movie | A Lot Like Love (2005)As Michelle | (Not seen) |
| movie | Wake Up, Ron Burgundy (2004) (AKA "Anchorman: Wake-Up Ron Burgundy")As Helen | (Not seen) |
| movie | Win a Date with Tad Hamilton! (2004)As Angelica | (Not seen) |
| movie | Anchorman: The Legend of Ron Burgundy (2004) (AKA "Action News")As Helen | (Not seen) |
| movie | How to Lose a Guy in 10 Days (2003) (AKA "How to Lose a Guy")As Michelle Rubin | (Not seen) |