| movie | SNL50: The Homecoming Concert (2025)As Self | (Not seen) |
| movie | Lilo & Stitch (2025)As Jumba (voice) | (Not seen) |
| movie | Thelma the Unicorn (2024)As Crusty Trucker (voice) | (Not seen) |
| movie | The Beanie Bubble (2023)As Ty | (Not seen) |
| movie | The Bob's Burgers Movie (2022)As Felix Fischoeder (voice) | (Not seen) |
| tv | Only Murders in the Building (2021)As Zach Galifianakis | (Not seen) |
| movie | Ron's Gone Wrong (2021)As Ron (voice) | (Not seen) |
| movie | Missing Link (2019)As Mr. Susan Link (voice) | (Not seen) |
| movie | Between Two Ferns: The Movie (2019)As Zach Galifianakis | (Not seen) |
| tv | My Next Guest Needs No Introduction with David Letterman (2018)As Self | (Not seen) |
| movie | Fahrenheit 11/9 (2018) | (Not seen) |
| movie | A Wrinkle in Time (2018)As The Happy Medium | (Not seen) |
| tv | Big Mouth (2017)As Gratitoad (voice) | (Not seen) |
| movie | The Lego Batman Movie (2017)As The Joker (voice) | (Not seen) |
| movie | Keeping Up with the Joneses (2016)As Jeff Gaffney | (Not seen) |
| movie | Masterminds (2015)As David Ghantt | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self | (Not seen) |
| movie | Muppets Most Wanted (2014)As Hobo Joe | (Not seen) |
| movie | Birdman or (The Unexpected Virtue of Ignorance) (2014)As Jake | (Not seen) |
| movie | Are You Here (2013)As Ben Baker | (Not seen) |
| movie | The Hangover Part III (2013)As Alan Garner | (Not seen) |
| tv | Comedians in Cars Getting Coffee (2012)As Self | (Not seen) |
| movie | Tim and Eric's Billion Dollar Movie (2012) (AKA "Tim & Eric's Billion Dollar Movie")As Jim Joe Kelly | (Not seen) |
| movie | The Campaign (2012)As Marty Huggins | (Not seen) |
| tv | Bob's Burgers (2011)As Felix Fischoeder (voice) | (Not seen) |
| movie | Puss in Boots (2011)As Humpty Dumpty (voice) | (Not seen) |
| movie | The Muppets (2011)As Hobo Joe | (Not seen) |
| movie | The Hangover Part II (2011)As Alan Garner | (Not seen) |
| movie | It's Kind of a Funny Story (2010)As Bobby | (Not seen) |
| movie | Due Date (2010)As Ethan Tremblay | (Not seen) |
| movie | Dinner for Schmucks (2010) (AKA "The Dinner")As Therman | (Not seen) |
| movie | Operation: Endgame (2010)As Hermit | (Not seen) |
| tv | Bored to Death (2009)As Ray Hueston | (Not seen) |
| movie | G-Force (2009) (AKA "Spy Animal: G-Force")As Ben | (Not seen) |
| movie | Youth in Revolt (2009)As Jerry | (Not seen) |
| movie | Up in the Air (2009)As Steve | (Not seen) |
| movie | The Hangover (2009)As Alan Garner | (Not seen) |
| movie | Visioneers (2008)As George | (Not seen) |
| movie | Gigantic (2008)As Homeless Man | (Not seen) |
| movie | What Happens in Vegas (2008)As Dave the bear | (Not seen) |
| movie | The Comedians of Comedy: Live at the Troubadour (2007)As Self | (Not seen) |
| movie | Super High Me (2007)As Self | (Not seen) |
| movie | Into the Wild (2007)As Kevin | (Not seen) |
| movie | Zach Galifianakis: Live at the Purple Onion (2006)As Himself / Seth Galifianakis | (Not seen) |
| tv | Real Time with Bill Maher (2003)As Self | (Not seen) |
| movie | Below (2002)As Weird Wally | (Not seen) |
| movie | Corky Romano (2001) (AKA "Corky Romano: 'Special' Agent")As Computer Hacker Dexter | (Not seen) |
| movie | Out Cold (2001) (AKA "10 to 1")As Luke | (Not seen) |
| movie | Bubble Boy (2001)As Bus Stop Man | (Not seen) |
| movie | Heartbreakers (2001) (AKA "Breakers")As Bill | (Not seen) |
| tv | The Daily Show (1996)As Self | (Not seen) |
| tv | The Simpsons (1989)As Lucas Bortner (voice) | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Host | (Not seen) |