| movie | Super/Man: The Christopher Reeve Story (2024)As Self | (Not seen) |
| tv | Shrinking (2023)As Randy(1 episode) | (Not seen) |
| movie | Bye Bye Barry (2023)As Self | (Not seen) |
| tv | American Rust (2021)As Det. Del Harris(19 episodes) | (Not seen) |
| tv | The Comey Rule (2020)As James Comey(2 episodes) | (Not seen) |
| tv | The Looming Tower (2018)As John O'Neill(10 episodes) | (Not seen) |
| movie | The Catcher Was a Spy (2018)As Bill Donovan | (Not seen) |
| tv | Godless (2017)As Frank Griffin(7 episodes) | (Not seen) |
| movie | Allegiant (2016) (AKA "The Divergent Series: Allegiant")As David | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self(4 episodes) | (Not seen) |
| movie | Steve Jobs (2015)As John Sculley | (Not seen) |
| movie | The Martian (2015) (AKA "The Martian 3D")As Teddy Sanders | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(3 episodes) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(1 episode) | (Not seen) |
| movie | Dumb and Dumber To (2014) (AKA "Dumb and Dumber 2")As Harry Dunne | (Not seen) |
| tv | The Newsroom (2012)As Will McAvoy(25 episodes) | (Not seen) |
| movie | Looper (2012)As Abe | (Not seen) |
| tv | Impractical Jokers (2011)As Self(1 episode) | (Not seen) |
| movie | Howl (2010)As Professor David Kirk | (Not seen) |
| movie | The Answer Man (2009)As Arlen Faber | (Not seen) |
| movie | Paper Man (2009)As Richard Dunn | (Not seen) |
| movie | Away We Go (2009)As Jerry Farlander | (Not seen) |
| movie | State of Play (2009)As Senator George Fergus | (Not seen) |
| movie | Space Chimps (2008)As Zartog (voice) | (Not seen) |
| movie | Traitor (2008)As Carter | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(1 episode) | (Not seen) |
| movie | Mama's Boy (2007)As Mert Rosenbloom | (Not seen) |
| movie | The Lookout (2007)As Lewis | (Not seen) |
| movie | RV (2006) (AKA "RV: Runaway Vacation")As Travis Gornicke | (Not seen) |
| movie | Because of Winn-Dixie (2005)As Preacher | (Not seen) |
| movie | The Squid and the Whale (2005)As Bernard Berkman | (Not seen) |
| movie | Good Night, and Good Luck. (2005) (AKA "Good Night, and Good Luck")As Sig Mickelson | (Not seen) |
| movie | The Five People You Meet in Heaven (2004)As Blue Man | (Not seen) |
| movie | Imaginary Heroes (2004)As Ben Travis | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(1 episode) | (Not seen) |
| movie | Super Sucker (2002)As Fred Barlow | (Not seen) |
| movie | Blood Work (2002)As Jasper 'Buddy' Noone | (Not seen) |
| movie | The Hours (2002)As Louis Waters | (Not seen) |
| tv | Family Guy (1999)As Jeff Daniels (voice)(1 episode) | (Not seen) |
| movie | All the Rage (1999) (AKA "It's the Rage")As Warren Harding | (Not seen) |
| movie | Pleasantville (1998)As Bill Johnson | (Not seen) |
| tv | The Daily Show (1996)As Self(2 episodes) | (Not seen) |
| movie | Fly Away Home (1996)As Thomas 'Tom' Alden | (Not seen) |
| movie | 101 Dalmatians (1996)As Roger Dearly | (Not seen) |
| movie | 2 Days in the Valley (1996) (AKA "Two Days in the Valley")As Alvin Strayer | (Not seen) |
| movie | Speed (1994)As Harold 'Harry' Temple | (Not seen) |
| movie | Dumb and Dumber (1994) (AKA "Dumb Happens")As Harry Dunne | (Not seen) |
| tv | Frasier (1993)As Doug (voice)(1 episode) | (Not seen) |
| movie | Welcome Home, Roxy Carmichael (1990)As Denton Webb | (Not seen) |
| movie | Arachnophobia (1990)As Dr. Ross Jennings | (Not seen) |
| movie | Radio Days (1987)As Biff Baxter | (Not seen) |
| movie | Something Wild (1986)As Charles Driggs | (Not seen) |
| movie | The Purple Rose of Cairo (1985)As Tom Baxter / Gil Shepherd | (Not seen) |
| tv | MTV Video Music Awards (1984)As Self - Presenter(1 episode) | (Not seen) |
| movie | Terms of Endearment (1983)As Flap Horton | (Not seen) |
| movie | Ragtime (1981) (AKA "Love and Glory")As P.C. O'Donnel | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Host(3 episodes) | (Not seen) |