| tv | The Floor (2024)As Self - Host(46 episodes) | (Not seen) |
| tv | Hot Ones Versus (2024)As Self(1 episode) | (Not seen) |
| movie | Brats (2024)As Self | (Not seen) |
| tv | Unstable (2023)As Ellis Dragon(16 episodes) | (Not seen) |
| movie | Dog Gone (2023)As John Marshall | (Not seen) |
| tv | The '80s: Top Ten (2022)As Self - Host(6 episodes) | (Not seen) |
| tv | The Pentaverate (2022)As Rob Lowe(6 episodes) | (Not seen) |
| movie | Attack of the Hollywood Cliches! (2021) (AKA "Attack of the Hollywood Clichés!")As Self | (Not seen) |
| tv | 9-1-1: Lone Star (2020)As Owen Strand(72 episodes) | (Not seen) |
| movie | A West Wing Special to Benefit When We All Vote (2020)As Sam Seaborn | (Not seen) |
| tv | Wild Bill (2019)As Bill Hixon(6 episodes) | (Not seen) |
| movie | The Knight Before Christmas (2019)As Derek | (Not seen) |
| movie | Super Troopers 2 (2018)As Guy Le Franc | (Not seen) |
| tv | The Orville (2017)As Darulio(2 episodes) | (Not seen) |
| movie | How to Be a Latin Lover (2017)As Rick | (Not seen) |
| tv | Chelsea (2016)As Self(1 episode) | (Not seen) |
| movie | Monster Trucks (2016)As Reece Tenneson | (Not seen) |
| movie | "Comedy Central Roasts" Comedy Central Roast of Rob Lowe (2016) (AKA "Comedy Central Roast of Rob Lowe")As Self | (Not seen) |
| tv | You, Me and the Apocalypse (2015)As Father Jude(10 episodes) | (Not seen) |
| tv | The Grinder (2015)As Dean Sanderson(22 episodes) | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self(1 episode) | (Not seen) |
| tv | Hot Ones (2015)As Self(1 episode) | (Not seen) |
| movie | Pocket Listing (2015)As Frank Hunter | (Not seen) |
| movie | Beautiful & Twisted (2015)As Ben Novack Jr. | (Not seen) |
| tv | Are You The One? (2014)As Francesco Salvitore | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(2 episodes) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(1 episode) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self(1 episode) | (Not seen) |
| movie | The Interview (2014)As Rob Lowe (uncredited) | (Not seen) |
| movie | Sex Tape (2014)As Hank | (Not seen) |
| movie | Behind the Candelabra (2013)As Dr. Jack Startz | (Not seen) |
| tv | Parks and Recreation (2009)As Chris Traeger(75 episodes) | (Not seen) |
| movie | The Invention of Lying (2009) (AKA "This Side of the Truth")As Brad Kessler | (Not seen) |
| tv | Californication (2007)As Eddie Nero(6 episodes) | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(1 episode) | (Not seen) |
| movie | Stir of Echoes: The Homecoming (2007) (AKA "Stir of Echoes 2: The Homecoming")As Ted Cogan | (Not seen) |
| movie | Brothers & Sisters: Family Album (2007)As Self/Robert McCallister | (Not seen) |
| movie | Thank You for Smoking (2005)As Jeff Megall | (Not seen) |
| tv | Salem's Lot (2004)As Ben Mears(2 episodes) | (Not seen) |
| tv | Real Time with Bill Maher (2003)As Self(2 episodes) | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(4 episodes) | (Not seen) |
| movie | View from the Top (2003) (AKA "Flight Girls")As Co-Pilot Steve Bench | (Not seen) |
| tv | American Idol (2002)As Self(1 episode) | (Not seen) |
| movie | Austin Powers in Goldmember (2002) (AKA "Austin Powers 3")As Middle Number Two | (Not seen) |
| tv | Hard Knocks (2001)(1 episode) | (Not seen) |
| movie | The Specials (2000)As The Weevil | (Not seen) |
| tv | Family Guy (1999)As Stanford Cordray (voice)(2 episodes) | (Not seen) |
| tv | The West Wing (1999)As Sam Seaborn(79 episodes) | (Not seen) |
| tv | Atomic Train (1999)As John Seger(2 episodes) | (Not seen) |
| movie | Austin Powers: The Spy Who Shagged Me (1999) (AKA "Austin Powers 2")As Young Number Two | (Not seen) |
| movie | Contact (1997)As Richard Rank | (Not seen) |
| movie | Austin Powers: International Man of Mystery (1997) (AKA "Austin Powers")As Decapitated Henchman's Friend (uncredited) | (Not seen) |
| tv | The Daily Show (1996)As Self(2 episodes) | (Not seen) |
| movie | Mulholland Falls (1996)As Hoodlum | (Not seen) |
| movie | Tommy Boy (1995)As Paul Burns (uncredited) | (Not seen) |
| tv | The Larry Sanders Show (1992)As Rob Lowe(1 episode) | (Not seen) |
| movie | Wayne's World (1992)As Benjamin Kane | (Not seen) |
| movie | Bad Influence (1990)As Alex | (Not seen) |
| tv | The Simpsons (1989)As Cousin Peter (voice)(1 episode) | (Not seen) |
| movie | Illegally Yours (1988)As Richard Dice | (Not seen) |
| movie | Masquerade (1988)As Tim Whalen | (Not seen) |
| movie | About Last Night (1986) (AKA "About Last Night...")As Danny Martin | (Not seen) |
| movie | Youngblood (1986)As Dean Youngblood | (Not seen) |
| movie | St. Elmo's Fire (1985)As Billy Hicks | (Not seen) |
| movie | The Hotel New Hampshire (1984)As John Berry | (Not seen) |
| movie | Class (1983)As Franklin 'Skip' Burroughs IV | (Not seen) |
| movie | The Outsiders (1983)As Sodapop Curtis | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Host(3 episodes) | (Not seen) |
| tv | The Oscars (1953)As Self(1 episode) | (Not seen) |