| movie | The Bride (2026) (AKA "The Bride!")As Dr. Euphronious | (Not seen) |
| tv | Apples Never Fall (2024)As Joy Delaney(7 episodes) | (Not seen) |
| movie | Nyad (2023)As Diana Nyad | (Not seen) |
| movie | Jerry and Marge Go Large (2022) (AKA "Jerry & Marge Go Large")As Marge Selbee | (Not seen) |
| movie | Death on the Nile (2022)As Euphemia Bouc | (Not seen) |
| movie | Georgetown (2019)As Amanda Brecht | (Not seen) |
| movie | The Report (2019)As Dianne Feinstein | (Not seen) |
| movie | Captain Marvel (2019)As Supreme Intelligence / Dr. Wendy Lawson | (Not seen) |
| movie | 20th Century Women (2016)As Dorothea Fields | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self(1 episode) | (Not seen) |
| movie | Danny Collins (2015)As Mary Sinclair | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self - Guest(1 episode) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(1 episode) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self(2 episodes) | (Not seen) |
| movie | Girl Most Likely (2012)As Zelda | (Not seen) |
| movie | Ruby Sparks (2012)As Gertrude | (Not seen) |
| movie | The Kids Are All Right (2010)As Nic | (Not seen) |
| movie | Mother and Child (2009)As Karen | (Not seen) |
| movie | The Women (2008)As Sylvia Fowler | (Not seen) |
| tv | The Graham Norton Show (2007)As Self - Guest(1 episode) | (Not seen) |
| movie | Running with Scissors (2006)As Deirdre Burroughs | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(3 episodes) | (Not seen) |
| movie | Open Range (2003)As Sue Barlow | (Not seen) |
| movie | What Planet Are You From? (2000)As Susan Anderson | (Not seen) |
| tv | The Sopranos (1999)As Annette Bening(1 episode) | (Not seen) |
| movie | In Dreams (1999)As Claire Cooper | (Not seen) |
| movie | American Beauty (1999)As Carolyn Burnham | (Not seen) |
| movie | The Siege (1998) (AKA "Against All Enemies")As Elise Kraft / Sharon Bridger | (Not seen) |
| tv | The Daily Show (1996)As Self(1 episode) | (Not seen) |
| movie | Mars Attacks! (1996)As Barbara Land | (Not seen) |
| movie | Richard III (1995)As Queen Elizabeth | (Not seen) |
| movie | The American President (1995) (AKA "Perfect Couple")As Sydney Ellen Wade | (Not seen) |
| movie | Guilty by Suspicion (1991)As Ruth Merrill | (Not seen) |
| movie | Regarding Henry (1991)As Sarah Turner | (Not seen) |
| movie | Bugsy (1991)As Virginia Hill | (Not seen) |
| movie | Postcards from the Edge (1990)As Evelyn Ames | (Not seen) |
| movie | The Grifters (1990)As Myra Langtry | (Not seen) |
| movie | Valmont (1989)As Merteuil | (Not seen) |
| movie | The Great Outdoors (1988) (AKA "Big Country")As Kate Craig | (Not seen) |
| tv | Miami Vice (1984)As Vicky(1 episode) | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Host(1 episode) | (Not seen) |
| tv | The Oscars (1953)As Self(6 episodes) | (Not seen) |