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In 1528, a Spanish expedition flounders off the coast of Florida with 600 lives lost. One survivor, Alvar Nunez Cabeza de Vaca, roams across the American continent searching for his Spanish comrades. Instead, he discovers the Iguase, an ancient Indian tribe. Over the next eight years, Cabeza de Vaca learns their mystical and mysterious culture, becoming a healer and a leader. But soon this New World collides with the Old World as Spanish conquistadors seek to enslave the Indians, and Cabeza de Vaca must confront his own people and his past.