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Donna Trenton is a frustrated suburban housewife whose life is a turmoil after her husband learns about her having an affair. Brett Camber is a young boy whose only companion is a Saint-Bernard named 'Cujo', who in turn is bitten by a rabid bat. Whilst Vic, Donna's husband is away on business, and thinking over his marital troubles, Donna and her 5-year-old son Tad take her Pinto to Brett Cambers' dad's car shop... the car fails, and 'Cujo' is very, very sick...