| tv | The Institute (2025)As Ms. Sigsby(8 episodes) | (Not seen) |
| movie | Counting Crows: Have You Seen Me Lately? (2025) (AKA "Music Box: Counting Crows: Have You Seen Me Lately?")As Self | (Not seen) |
| tv | Elsbeth (2024)As Freya Frostad(2 episodes) | (Not seen) |
| movie | Omni Loop (2024)As Zoya Lowe | (Not seen) |
| movie | Woody Woodpecker Goes to Camp (2024)As Angie | (Not seen) |
| movie | Seneca (2023)As Agrippina | (Not seen) |
| movie | Red Sparrow (2018)As Stephanie Boucher | (Not seen) |
| tv | Mr. Mercedes (2017)As Janey Patterson(10 episodes) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self(1 episode) | (Not seen) |
| movie | Behaving Badly (2014)As Lucy Stevens / Saint Lola | (Not seen) |
| tv | The Blacklist (2013)As Naomi Hyland(4 episodes) | (Not seen) |
| movie | RED 2 (2013) (AKA "RED Returns")As Sarah Ross | (Not seen) |
| movie | R.I.P.D. (2013) (AKA "Ghost Agent: R.I.P.D.")As Proctor | (Not seen) |
| movie | Howl (2010)As Gail Potter | (Not seen) |
| movie | Red (2010)As Sarah | (Not seen) |
| movie | Solitary Man (2009)As Jordan | (Not seen) |
| movie | The Assassination of Jesse James: Death of an Outlaw (2008)As Self | (Not seen) |
| movie | The Spiderwick Chronicles (2008)As Helen Grace | (Not seen) |
| movie | The Assassination of Jesse James by the Coward Robert Ford (2007)As Zee James | (Not seen) |
| tv | Weeds (2005)As Nancy Botwin(102 episodes) | (Not seen) |
| movie | Romance & Cigarettes (2005)As Constance | (Not seen) |
| movie | Saved! (2004)As Lillian | (Not seen) |
| tv | Angels in America (2003)As Harper Pitt(6 episodes) | (Not seen) |
| movie | Red Dragon (2002) (AKA "Roter Drache")As Molly Graham | (Not seen) |
| movie | Pipe Dream (2001)As Toni Edelman | (Not seen) |
| tv | The West Wing (1999)As Amy Gardner(23 episodes) | (Not seen) |
| movie | The Five Senses (1999)As Rona | (Not seen) |
| movie | Goodbye Lover (1998) (AKA "Patricia Arquette's Goodbye Lover")As Peggy Blane | (Not seen) |
| movie | Murder in Mind (1997)As Caroline Walker | (Not seen) |
| movie | The Portrait of a Lady (1996)As Henrietta Stackpole | (Not seen) |
| movie | Boys on the Side (1995)As Robin | (Not seen) |
| movie | Bullets Over Broadway (1994)As Ellen | (Not seen) |
| movie | The Client (1994)As Dianne Sway | (Not seen) |
| movie | Mr. Wonderful (1993)As Rita | (Not seen) |
| movie | Fried Green Tomatoes (1991)As Ruth Jamison | (Not seen) |
| movie | Grand Canyon (1991)As Dee | (Not seen) |
| movie | Longtime Companion (1989)As Lisa | (Not seen) |