| movie | Elio (2025)As Aunt Olga (voice) | (Not seen) |
| movie | Avatar: Fire and Ash (2025)As Neytiri | (Not seen) |
| tv | Hot Ones Versus (2024)As Self(1 episode) | (Not seen) |
| movie | Emilia Pérez (2024)As Rita | (Not seen) |
| tv | Lioness (2023)As Joe McNamara(16 episodes) | (Not seen) |
| movie | Guardians of the Galaxy Vol. 3 (2023) (AKA "Guardians of the Galaxy Volume 3")As Gamora | (Not seen) |
| movie | Amsterdam (2022)As Irma | (Not seen) |
| movie | Avatar: The Way of Water (2022)As Neytiri | (Not seen) |
| movie | The Adam Project (2022)As Laura | (Not seen) |
| tv | Marvel Studios Legends (2021)As Gamora (archive footage) (uncredited)(9 episodes) | (Not seen) |
| movie | Vivo (2021)As Rosa (voice) | (Not seen) |
| tv | Home Movie: The Princess Bride (2020)As Princess Buttercup(1 episode) | (Not seen) |
| movie | Vampires vs. the Bronx (2020)As Becky | (Not seen) |
| movie | Missing Link (2019)As Adelina Fortnight (voice) | (Not seen) |
| movie | Avengers: Endgame (2019)As Gamora | (Not seen) |
| tv | James Cameron's Story of Science Fiction (2018)As Self(1 episode) | (Not seen) |
| movie | Avengers: Infinity War (2018)As Gamora | (Not seen) |
| movie | I Kill Giants (2017)As Mrs. Mollé | (Not seen) |
| movie | Guardians of the Galaxy Vol. 2 (2017) (AKA "Guardians of the Galaxy 2")As Gamora | (Not seen) |
| movie | Live by Night (2016)As Graciella Suarez | (Not seen) |
| movie | Star Trek Beyond (2016) (AKA "Star Trek 3")As Lieutenant Uhura | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self - Guest(1 episode) | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self(1 episode) | (Not seen) |
| tv | Hot Ones (2015)As Self(1 episode) | (Not seen) |
| tv | Rosemary's Baby (2014)As Rosemary Woodhouse(2 episodes) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(3 episodes) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(1 episode) | (Not seen) |
| movie | Infinitely Polar Bear (2014)As Maggie | (Not seen) |
| movie | The Book of Life (2014)As Maria (voice) | (Not seen) |
| movie | Guardians of the Galaxy (2014) (AKA "G.O.T.G.")As Gamora | (Not seen) |
| movie | Blood Ties (2013)As Vanessa | (Not seen) |
| movie | Out of the Furnace (2013)As Lena Taylor | (Not seen) |
| movie | Star Trek Into Darkness (2013) (AKA "2")As Nyota Uhura | (Not seen) |
| movie | The Words (2012)As Dora Jansen | (Not seen) |
| movie | Colombiana (2011)As Cataleya Restrepo | (Not seen) |
| movie | Burning Palms (2010)As Sarah Cotton | (Not seen) |
| movie | Takers (2010)As Rachel Jansen | (Not seen) |
| movie | Death at a Funeral (2010)As Elaine | (Not seen) |
| movie | Avatar: Creating the World of Pandora (2010)As Self | (Not seen) |
| movie | The Losers (2010)As Aisha al-Fadhil | (Not seen) |
| movie | Avatar (2009)As Neytiri | (Not seen) |
| movie | Star Trek (2009) (AKA "Star Trek: The Future Begins")As Nyota Uhura | (Not seen) |
| movie | The Skeptic (2008)As Cassie | (Not seen) |
| movie | Vantage Point (2008)As Angie Jones | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(2 episodes) | (Not seen) |
| movie | After Sex (2007)As Kat | (Not seen) |
| movie | Guess Who (2005)As Theresa Jones | (Not seen) |
| movie | Dirty Deeds (2005) (AKA "Dirtier Deeds")As Rachel Buff | (Not seen) |
| tv | Project Runway (2004)As Self - Guest Judge(2 episodes) | (Not seen) |
| movie | Haven (2004)As Andrea | (Not seen) |
| movie | The Terminal (2004) (AKA "Terminal")As Dolores Torres | (Not seen) |
| movie | Pirates of the Caribbean: The Curse of the Black Pearl (2003) (AKA "P.O.T.C.")As Anamaria | (Not seen) |
| movie | Drumline (2002)As Laila | (Not seen) |
| movie | Crossroads (2002) (AKA "Not a Girl")As Kit | (Not seen) |
| movie | Snipes (2001)As Cheryl | (Not seen) |
| movie | Center Stage (2000)As Eva Rodríguez | (Not seen) |
| tv | Law & Order: Special Victims Unit (1999)As Gabrielle Vega(1 episode) | (Not seen) |
| tv | Law & Order (1990)As Belinca(1 episode) | (Not seen) |
| tv | The Oscars (1953)As Self(4 episodes) | (Not seen) |