| tv | The Four Seasons (2025)As Nick(8 episodes) | (Not seen) |
| movie | Mountainhead (2025)As Randall Garrett | (Not seen) |
| movie | Despicable Me 4 (2024)As Gru (voice) | (Not seen) |
| movie | IF (2024)As Blue (voice) | (Not seen) |
| movie | Asteroid City (2023)As Motel Manager | (Not seen) |
| tv | The Patient (2022)As Alan Strauss(10 episodes) | (Not seen) |
| movie | Minions: The Rise of Gru (2022)As Gru (voice) | (Not seen) |
| tv | Space Force (2020)As General Mark R. Naird(17 episodes) | (Not seen) |
| movie | Irresistible (2020)As Gary Zimmer | (Not seen) |
| tv | The Morning Show (2019)As Mitch Kessler(16 episodes) | (Not seen) |
| movie | Beautiful Boy (2018)As David Sheff | (Not seen) |
| movie | Welcome to Marwen (2018)As Mark Hogancamp | (Not seen) |
| movie | Vice (2018)As Donald Rumsfeld | (Not seen) |
| movie | Battle of the Sexes (2017)As Bobby Riggs | (Not seen) |
| movie | Despicable Me 3 (2017)As Gru / Dru (voice) | (Not seen) |
| movie | Café Society (2016)As Phil Stern | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self - Guest(5 episodes) | (Not seen) |
| movie | The Big Short (2015)As Mark Baum | (Not seen) |
| movie | Minions (2015)As Gru (voice) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self - Guest(3 episodes) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(1 episode) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self(1 episode) | (Not seen) |
| movie | Alexander and the Terrible, Horrible, No Good, Very Bad Day (2014)As Ben Cooper | (Not seen) |
| movie | Foxcatcher (2014) (AKA "Mark v. Du Pont: The True Story of a Shocking Murder")As John du Pont | (Not seen) |
| movie | Anchorman 2: The Legend Continues (2013) (AKA "Anchorman 2")As Brick Tamland | (Not seen) |
| movie | The Way Way Back (2013) (AKA "The Way, Way Back")As Trent Ramsey | (Not seen) |
| movie | Despicable Me 2 (2013)As Gru (voice) | (Not seen) |
| movie | The Incredible Burt Wonderstone (2013)As Burt Wonderstone | (Not seen) |
| movie | Hope Springs (2012)As Dr. Bernie Feld | (Not seen) |
| movie | Seeking a Friend for the End of the World (2012)As Dodge Petersen | (Not seen) |
| movie | Crazy, Stupid, Love. (2011) (AKA "Love Again")As Cal Weaver | (Not seen) |
| movie | Dinner for Schmucks (2010) (AKA "The Dinner")As Barry | (Not seen) |
| movie | Despicable Me (2010)As Gru (voice) | (Not seen) |
| movie | Date Night (2010)As Phil Foster | (Not seen) |
| movie | Horton Hears a Who! (2008) (AKA "Dr. Seuss' Horton Hears a Who")As The Mayor of Whoville (voice) | (Not seen) |
| movie | Get Smart (2008)As Maxwell Smart | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(4 episodes) | (Not seen) |
| movie | Dan in Real Life (2007)As Dan Burns | (Not seen) |
| movie | Knocked Up (2007)As Himself (uncredited) | (Not seen) |
| movie | Evan Almighty (2007) (AKA "Bruce Almighty 2")As Evan Baxter | (Not seen) |
| movie | Over the Hedge (2006)As Hammy (voice) | (Not seen) |
| movie | Little Miss Sunshine (2006)As Frank Ginsberg | (Not seen) |
| tv | The Office (2005)As Michael Scott(140 episodes) | (Not seen) |
| movie | Bewitched (2005)As Uncle Arthur | (Not seen) |
| movie | The 40-Year-Old Virgin (2005) (AKA "The 40 Year-Old Virgin")As Andy Stitzer | (Not seen) |
| movie | Wake Up, Ron Burgundy (2004) (AKA "Anchorman: Wake-Up Ron Burgundy")As Brick Tamland | (Not seen) |
| movie | Melinda and Melinda (2004) (AKA "Melinda & Melinda")As Walt | (Not seen) |
| movie | Anchorman: The Legend of Ron Burgundy (2004) (AKA "Action News")As Brick Tamland | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self - Guest(2 episodes) | (Not seen) |
| movie | Bruce Almighty (2003)As Evan Baxter | (Not seen) |
| movie | Homegrown (1998) (AKA "Wild Smokers")As Party Extra with Funny Pants (uncredited) | (Not seen) |
| tv | The Daily Show (1996)As Self(8 episodes) | (Not seen) |
| movie | Curly Sue (1991)As Tesio | (Not seen) |
| tv | The Simpsons (1989)As Dan Gillick (voice)(1 episode) | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Cameo (uncredited)(5 episodes) | (Not seen) |
| tv | The Oscars (1953)As Self(1 episode) | (Not seen) |