| movie | Joker: Folie à Deux (2024)As Maryanne Stewart | (Not seen) |
| movie | The Adam Project (2022)As Maya Sorian | (Not seen) |
| tv | Brand New Cherry Flavor (2021)As Boro(8 episodes) | (Not seen) |
| movie | The Croods: A New Age (2020)As Ugga Crood (voice) | (Not seen) |
| tv | Modern Love (2019)As Julie(1 episode) | (Not seen) |
| tv | Forever (2018)As Kase(5 episodes) | (Not seen) |
| tv | Kidding (2018)As Deirdre Perera(20 episodes) | (Not seen) |
| movie | Sicario: Day of the Soldado (2018)As Cynthia Foards | (Not seen) |
| movie | Incredibles 2 (2018)As Evelyn Deavor (voice) | (Not seen) |
| movie | November Criminals (2017)As Fiona | (Not seen) |
| movie | Get Out (2017)As Missy Armitage | (Not seen) |
| movie | Elephant Song (2014)As Nurse Susan Peterson | (Not seen) |
| movie | Jackass Presents: Bad Grandpa (2013)As Ellie Zisman | (Not seen) |
| movie | Enough Said (2013)As Marianne | (Not seen) |
| movie | Begin Again (2013) (AKA "Can a Song Save Your Life?")As Miriam Hart | (Not seen) |
| movie | Captain Phillips (2013)As Andrea Phillips | (Not seen) |
| movie | The Croods (2013)As Ugga Crood (voice) | (Not seen) |
| movie | A Late Quartet (2012)As Juliette Gelbart | (Not seen) |
| movie | Trust (2010)As Lynn Cameron | (Not seen) |
| movie | Percy Jackson & the Olympians: The Lightning Thief (2010) (AKA "Percy Jackson and the Lightning Thief")As Sally Jackson | (Not seen) |
| movie | The Soloist (2009)As Mary Weston | (Not seen) |
| movie | Where the Wild Things Are (2009)As Connie | (Not seen) |
| movie | Synecdoche, New York (2008)As Adele Lack | (Not seen) |
| movie | What Just Happened (2008)As Lou Tarnow | (Not seen) |
| movie | An American Crime (2007)As Gertrude Baniszewski | (Not seen) |
| movie | Into the Wild (2007)As Jan Burres | (Not seen) |
| movie | Friends with Money (2006)As Christine | (Not seen) |
| movie | The Ballad of Jack and Rose (2005) (AKA "Rose and the Snake")As Kathleen | (Not seen) |
| movie | The 40-Year-Old Virgin (2005) (AKA "The 40 Year-Old Virgin")As Trish Piedmont | (Not seen) |
| movie | Capote (2005)As Harper Lee | (Not seen) |
| movie | The Interpreter (2005)As Dot Woods | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(1 episode) | (Not seen) |
| movie | S1m0ne (2002) (AKA "Simone")As Elaine Christian | (Not seen) |
| movie | Full Frontal (2002) (AKA "How to Survive a Hotel Room Fire")As Lee | (Not seen) |
| movie | Adaptation. (2002) (AKA "The Orchid Thief")As Herself (uncredited) | (Not seen) |
| movie | Death to Smoochy (2002)As Nora Wells | (Not seen) |
| movie | Being John Malkovich (1999)As Maxine Lund | (Not seen) |
| movie | 8MM (1999) (AKA "8 Millimeter")As Amy Welles | (Not seen) |
| movie | Your Friends and Neighbors (1998) (AKA "Friends and Neighbors")As Terri | (Not seen) |
| movie | Out of Sight (1998)As Adele | (Not seen) |
| movie | The Real Blonde (1997)As Mary | (Not seen) |
| tv | The Daily Show (1996)As Self(1 episode) | (Not seen) |
| movie | Living in Oblivion (1995)As Nicole Springer | (Not seen) |
| movie | Switch (1991) (AKA "Blake Edwards' Switch")As Steve's Secretary | (Not seen) |
| tv | Seinfeld (1989)As Nina West(1 episode) | (Not seen) |
| movie | About Last Night (1986) (AKA "About Last Night...")As Cocktail Waitress | (Not seen) |
| tv | The Oscars (1953)As Self(2 episodes) | (Not seen) |