| The Phoenician Scheme (2025)As Leland | (Not seen) |
| SNL50: The Homecoming Concert (2025)As Self | (Not seen) |
| Freaky Tales (2024)As Hank, Video Store Owner | (Not seen) |
| Here (2024)As Richard | (Not seen) |
| Asteroid City (2023)As Stanley Zak | (Not seen) |
| A Man Called Otto (2022)As Otto Anderson | (Not seen) |
| Halftime (2022) (AKA "Jennifer Lopez: Halftime")As Self | (Not seen) |
| Pinocchio (2022)As Geppetto | (Not seen) |
| Elvis (2022)As Colonel Tom Parker | (Not seen) |
| Finch (2021)As Finch | (Not seen) |
| News of the World (2020)As Captain Jefferson Kyle Kidd | (Not seen) |
| Borat Subsequent Moviefilm (2020)As Self | (Not seen) |
| Greyhound (2020)As Commander Krause | (Not seen) |
| A Beautiful Day in the Neighborhood (2019)As Fred Rogers | (Not seen) |
| Toy Story 4 (2019)As Woody (voice) | (Not seen) |
| The Post (2017)As Ben Bradlee | (Not seen) |
| The Circle (2017)As Eamon Bailey | (Not seen) |
| Inferno (2016)As Robert Langdon | (Not seen) |
| Sully (2016) (AKA "Miracle on the Hudson")As Chesley 'Sully' Sullenberger | (Not seen) |
| Bridge of Spies (2015)As James B. Donovan | (Not seen) |
| Killing Lincoln (2013)As Himself - Narrator | (Not seen) |
| Saving Mr. Banks (2013)As Walt Disney | (Not seen) |
| Captain Phillips (2013)As Captain Richard Phillips | (Not seen) |
| Cloud Atlas (2012)As Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry | (Not seen) |
| Extremely Loud & Incredibly Close (2011)As Thomas Schell | (Not seen) |
| Larry Crowne (2011)As Larry Crowne | (Not seen) |
| Toy Story 3 (2010) (AKA "3")As Woody (voice) | (Not seen) |
| Angels & Demons (2009)As Robert Langdon | (Not seen) |
| The Great Buck Howard (2008)As Mr. Gable | (Not seen) |
| Saturday Night Live in the '90s: Pop Culture Nation (2007) | (Not seen) |
| Charlie Wilson's War (2007)As Charlie Wilson | (Not seen) |
| The Simpsons Movie (2007)As Himself (voice) | (Not seen) |
| The Queen (2006) | (Not seen) |
| Cars (2006) (AKA "Route 66")As Woody Car (voice) | (Not seen) |
| The Da Vinci Code (2006) (AKA "The DaVinci Code")As Robert Langdon | (Not seen) |
| The Polar Express (2004)As Hero Boy / Father / Conductor / Hobo / Scrooge / Santa Claus | (Not seen) |
| The Terminal (2004) (AKA "Terminal")As Viktor Navorski | (Not seen) |
| The Ladykillers (2004)As Professor G.H. Dorr | (Not seen) |
| Catch Me If You Can (2002)As Carl Hanratty | (Not seen) |
| Road to Perdition (2002)As Michael Sullivan | (Not seen) |
| Behind the Scenes: Cast Away (2000) | (Not seen) |
| Cast Away (2000)As Chuck Noland | (Not seen) |
| Toy Story 2 (1999)As Woody (voice) | (Not seen) |
| The Green Mile (1999) (AKA "Stephen King's The Green Mile")As Paul Edgecomb | (Not seen) |
| You've Got Mail (1998) (AKA "You Have Mail")As Joe Fox | (Not seen) |
| Saving Private Ryan (1998)As Captain John H. Miller | (Not seen) |
| That Thing You Do! (1996)As Mr. White | (Not seen) |
| The Celluloid Closet (1995)As Himself | (Not seen) |
| Toy Story (1995)As Woody (voice) | (Not seen) |
| Apollo 13 (1995)As Jim Lovell | (Not seen) |
| Forrest Gump (1994)As Forrest Gump | (Not seen) |
| Sleepless in Seattle (1993)As Sam Baldwin | (Not seen) |
| Philadelphia (1993) (AKA "At Risk")As Andrew Beckett | (Not seen) |
| Radio Flyer (1992)As Older Mike/Narrator (uncredited) | (Not seen) |
| A League of Their Own (1992)As Jimmy Dugan | (Not seen) |
| Joe Versus the Volcano (1990)As Joe Banks | (Not seen) |
| The Bonfire of the Vanities (1990)As Sherman McCoy | (Not seen) |
| Turner & Hooch (1989)As Scott Turner | (Not seen) |
| The 'Burbs (1989) (AKA "Life in the Burbs")As Ray Peterson | (Not seen) |
| Punchline (1988)As Steven Gold | (Not seen) |
| Big (1988)As Joshua "Josh" Baskin | (Not seen) |
| Dragnet (1987)As Pep Streebeck | (Not seen) |
| Nothing in Common (1986)As David Basner | (Not seen) |
| The Money Pit (1986)As Walter Fielding, Jr. | (Not seen) |
| The Man with One Red Shoe (1985)As Richard Harlan Drew | (Not seen) |
| Splash (1984)As Allen Bauer | (Not seen) |
| Bachelor Party (1984)As Rick Gassko | (Not seen) |
| Mazes and Monsters (1982)As Robbie Wheeling | (Not seen) |