| movie | Spoiler Alert (2022)As Michael Ausiello | (Not seen) |
| tv | Hollywood (2020)As Henry Wilson(7 episodes) | (Not seen) |
| movie | The Boys in the Band (2020)As Michael | (Not seen) |
| movie | Extremely Wicked, Shockingly Evil and Vile (2019)As Larry Simpson | (Not seen) |
| tv | Young Sheldon (2017)As Sheldon Cooper (voice)(141 episodes) | (Not seen) |
| tv | Chelsea (2016)As Self(1 episode) | (Not seen) |
| movie | Hidden Figures (2016)As Paul Stafford | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self - Guest(1 episode) | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self - Guest(1 episode) | (Not seen) |
| movie | Visions (2015)As Dr. Mathison | (Not seen) |
| movie | Home (2015)As Oh (voice) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(6 episodes) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self(5 episodes) | (Not seen) |
| movie | Elf: Buddy's Musical Christmas (2014)As Buddy (voice) | (Not seen) |
| movie | Wish I Was Here (2014)As Paul | (Not seen) |
| movie | The Big Year (2011)As Crane | (Not seen) |
| movie | The Muppets (2011)As Human Walter | (Not seen) |
| tv | iCarly (2007)As Caleb(1 episode) | (Not seen) |
| tv | The Big Bang Theory (2007)As Sheldon Cooper(279 episodes) | (Not seen) |
| movie | 10 Items or Less (2006)As Receptionist | (Not seen) |
| movie | School for Scoundrels (2006) (AKA "The Better Man")As Classmate | (Not seen) |
| movie | Garden State (2004) (AKA "Large")As Tim | (Not seen) |
| tv | Real Time with Bill Maher (2003)As Self(1 episode) | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self - Guest(2 episodes) | (Not seen) |
| tv | Family Guy (1999)As Sheldon Cooper (voice)(2 episodes) | (Not seen) |
| tv | The Daily Show (1996)As Self(2 episodes) | (Not seen) |
| tv | The Simpsons (1989)As Jim Parsons (voice)(1 episode) | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Host(1 episode) | (Not seen) |