| movie | Suncoast (2024)As Kristine | (Not seen) |
| movie | The Miracle Club (2023)As Chrissie Ahearn | (Not seen) |
| movie | Robin Williams: Come Inside My Mind (2018) | (Not seen) |
| tv | Ozark (2017)As Wendy Byrde(44 episodes) | (Not seen) |
| movie | Red Nose Day Actually (2017)As Sarah (US version) | (Not seen) |
| movie | The Dinner (2017)As Claire Lohman | (Not seen) |
| movie | Teenage Mutant Ninja Turtles: Out of the Shadows (2016)As Chief Vincent | (Not seen) |
| movie | Genius (2016)As Louise Saunders | (Not seen) |
| movie | Nocturnal Animals (2016)As Anne Sutton | (Not seen) |
| movie | Sully (2016) (AKA "Miracle on the Hudson")As Lorraine Sullenberger | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self(1 episode) | (Not seen) |
| movie | Mr. Holmes (2015)As Mrs. Munro | (Not seen) |
| tv | BoJack Horseman (2014)As Laura Linney (voice)(1 episode) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(1 episode) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(1 episode) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self(1 episode) | (Not seen) |
| movie | The Fifth Estate (2013) (AKA "The 5ifth Estate")As Sarah Shaw | (Not seen) |
| movie | Hyde Park on Hudson (2012)As Daisy | (Not seen) |
| movie | Arthur Christmas (2011) (AKA "Arthur Christmas in 3D")As North Pole Computer (voice) | (Not seen) |
| movie | The Details (2011)As Lila | (Not seen) |
| movie | The Other Man (2008)As Lisa | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(2 episodes) | (Not seen) |
| movie | The Nanny Diaries (2007)As Mrs. X | (Not seen) |
| movie | The Savages (2007)As Wendy Savage | (Not seen) |
| movie | Breach (2007) (AKA "Hanssen")As Kate Burroughs | (Not seen) |
| movie | Man of the Year (2006)As Eleanor Green | (Not seen) |
| movie | The Squid and the Whale (2005)As Joan Berkman | (Not seen) |
| movie | The Exorcism of Emily Rose (2005) (AKA "The Exorcism of Anneliese Michel")As Erin Bruner | (Not seen) |
| movie | P.S. (2004)As Louise Harrington | (Not seen) |
| movie | Kinsey (2004)As Clara McMillen | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(1 episode) | (Not seen) |
| movie | Love Actually (2003) (AKA "Love Actually Is All Around")As Sarah | (Not seen) |
| movie | Mystic River (2003)As Annabeth Markum | (Not seen) |
| movie | The Life of David Gale (2003)As Constance Hallaway | (Not seen) |
| movie | The Laramie Project (2002)As Sherry Johnson | (Not seen) |
| movie | The Mothman Prophecies (2002) (AKA "Mothman")As Connie Mills | (Not seen) |
| movie | Wild Iris (2001)As Iris Bravard | (Not seen) |
| movie | You Can Count on Me (2000)As Samantha Prescott | (Not seen) |
| movie | The Truman Show (1998)As Meryl Burbank / Hannah Gill | (Not seen) |
| tv | King of the Hill (1997)As Marlene (voice)(1 episode) | (Not seen) |
| movie | Absolute Power (1997)As Kate Whitney | (Not seen) |
| tv | The Daily Show (1996)As Self(1 episode) | (Not seen) |
| movie | Primal Fear (1996)As Janet Venable | (Not seen) |
| movie | Congo (1995)As Dr. Karen Ross | (Not seen) |
| movie | A Simple Twist of Fate (1994)As Nancy Lambert Newland | (Not seen) |
| tv | Frasier (1993)As Charlotte Connor(6 episodes) | (Not seen) |
| movie | Searching for Bobby Fischer (1993) (AKA "Innocent Moves")As School Teacher | (Not seen) |
| movie | Dave (1993)As Randi | (Not seen) |
| movie | Lorenzo's Oil (1992)As Young Teacher | (Not seen) |
| tv | Law & Order (1990)As Martha Bowen(1 episode) | (Not seen) |
| tv | The Oscars (1953)As Self(3 episodes) | (Not seen) |