| tv | The Veil (2024)As Imogen Salter(6 episodes) | (Not seen) |
| movie | Shell (2024)As Samantha Lake | (Not seen) |
| movie | Next Goal Wins (2023)As Gail | (Not seen) |
| tv | Shining Girls (2022)As Kirby Mazrachi(8 episodes) | (Not seen) |
| movie | The French Dispatch (2021) (AKA "The French Dispatch of the Liberty, Kansas Evening Sun")As Alumna | (Not seen) |
| movie | A West Wing Special to Benefit When We All Vote (2020)As Self | (Not seen) |
| movie | Shirley (2020)As Shirley Jackson | (Not seen) |
| movie | The Invisible Man (2020)As Cecilia Kass | (Not seen) |
| movie | Light of My Life (2019)As Mom | (Not seen) |
| movie | The Kitchen (2019)As Claire Walsh | (Not seen) |
| movie | Us (2019)As Kitty Tyler / Dahlia | (Not seen) |
| movie | The Old Man & the Gun (2018)As Dorothy | (Not seen) |
| tv | The Handmaid's Tale (2017)As June Osborne / Offred / Ofjoseph(66 episodes) | (Not seen) |
| movie | The Square (2017)As Anne | (Not seen) |
| tv | Chelsea (2016)As Self(1 episode) | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self - Guest(1 episode) | (Not seen) |
| movie | High-Rise (2015)As Helen Wilder | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(1 episode) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(2 episodes) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self(3 episodes) | (Not seen) |
| movie | The One I Love (2014)As Sophie | (Not seen) |
| tv | Top of the Lake (2013)As Det. Robin Griffin(13 episodes) | (Not seen) |
| movie | On the Road (2012)As Galatea Dunkel / Helen Hinkle | (Not seen) |
| movie | Green Lantern: Emerald Knights (2011)As Arisia Rrab | (Not seen) |
| movie | Get Him to the Greek (2010) (AKA "American Trip")As Daphne Binks | (Not seen) |
| movie | Did You Hear About the Morgans? (2009)As Jackie Drake | (Not seen) |
| tv | Mad Men (2007)As Peggy Olson(92 episodes) | (Not seen) |
| movie | Day Zero (2007)As Patricia | (Not seen) |
| tv | Grey's Anatomy (2005)As Nina Rogerson(1 episode) | (Not seen) |
| tv | Project Runway (2004)As Self - Guest Judge(1 episode) | (Not seen) |
| movie | The Missing (2003) (AKA "The Last Ride")As Anne | (Not seen) |
| movie | Virgin (2003)As Jessie Reynolds | (Not seen) |
| tv | The West Wing (1999)As Zoey Bartlet(25 episodes) | (Not seen) |
| movie | Anywhere But Here (1999)As Rachel | (Not seen) |
| movie | Girl, Interrupted (1999)As Polly Clark | (Not seen) |
| tv | The Practice (1997)As Jessica Palmer(1 episode) | (Not seen) |
| tv | The Daily Show (1996)As Self(1 episode) | (Not seen) |
| movie | The Last Supper (1995)As Jenny Tyler | (Not seen) |
| movie | Suburban Commando (1991)As Little Girl | (Not seen) |
| tv | The Simpsons (1989)As Gretchen (voice)(1 episode) | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Cameo (uncredited)(2 episodes) | (Not seen) |