| movie | Nonnas (2025)As Gia | (Not seen) |
| movie | Gracie and Pedro: Pets to the Rescue (2024) (AKA "Gracie & Pedro: Pets to the Rescue")As Shades (voice) | (Not seen) |
| movie | Super/Man: The Christopher Reeve Story (2024)As Self | (Not seen) |
| movie | The Six Triple Eight (2024)As Eleanor Roosevelt | (Not seen) |
| movie | Blue Beetle (2023)As Victoria Kord | (Not seen) |
| movie | Maybe I Do (2023)As Monica | (Not seen) |
| movie | Jolt (2021)As Woman with No Name | (Not seen) |
| movie | Derek DelGaudio's In & Of Itself (2020) | (Not seen) |
| movie | Blackbird (2019)As Lily | (Not seen) |
| movie | The Jesus Rolls (2019)As Jean | (Not seen) |
| tv | The Alienist (2018)As Dr. Jerri Nielsen | (Not seen) |
| tv | FEUD (2017)As Bette Davis(8 episodes) | (Not seen) |
| movie | A Bad Moms Christmas (2017)As Isis Dunkler | (Not seen) |
| tv | Search Party (2016)As Lylah(2 episodes) | (Not seen) |
| tv | Chelsea (2016)As Self(1 episode) | (Not seen) |
| movie | Zoolander 2 (2016) (AKA "2oolander")As Susan Sarandon (uncredited) | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self(1 episode) | (Not seen) |
| movie | April and the Extraordinary World (2015)As Chimène (English DUB) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(2 episodes) | (Not seen) |
| movie | Tammy (2014)As Pearl | (Not seen) |
| movie | The Calling (2014)As Hazel Micallef | (Not seen) |
| tv | Ray Donovan (2013)As Samantha Winslow(13 episodes) | (Not seen) |
| tv | Rick and Morty (2013)As Dr. Helen Wong (voice)(4 episodes) | (Not seen) |
| movie | The Last of Robin Hood (2013)As Florence Aadland | (Not seen) |
| movie | Snitch (2013)As Joanne Keeghan | (Not seen) |
| movie | The Big Wedding (2013)As Bebe McBride | (Not seen) |
| movie | Robot & Frank (2012)As Jennifer | (Not seen) |
| movie | That's My Boy (2012)As Mary McGarricle | (Not seen) |
| movie | The Company You Keep (2012)As Sharon Solarz | (Not seen) |
| movie | The Perks of Being a Wallflower (2012) | (Not seen) |
| movie | Arbitrage (2012)As Ellen Miller | (Not seen) |
| movie | Cloud Atlas (2012)As Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess | (Not seen) |
| movie | Jeff, Who Lives at Home (2011)As Sharon | (Not seen) |
| movie | Beastie Boys: Fight for Your Right Revisited (2011) (AKA "Fight for Your Right Revisited")As Mother | (Not seen) |
| movie | You Don't Know Jack (2010)As Janet Good | (Not seen) |
| movie | Wall Street: Money Never Sleeps (2010) (AKA "Wall Street")As Sylvia Moore | (Not seen) |
| movie | Peacock (2010)As Fanny Crill | (Not seen) |
| movie | The Greatest (2009)As Grace Brewer | (Not seen) |
| movie | Solitary Man (2009)As Nancy | (Not seen) |
| movie | Leaves of Grass (2009)As Daisy Kincaid | (Not seen) |
| movie | The Lovely Bones (2009)As Grandma Lynn | (Not seen) |
| movie | Speed Racer (2008) (AKA "Speed Racer: The IMAX Experience")As Mom Racer | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(1 episode) | (Not seen) |
| movie | Saturday Night Live in the '90s: Pop Culture Nation (2007)As Self | (Not seen) |
| movie | In the Valley of Elah (2007)As Joan Deerfield | (Not seen) |
| movie | Enchanted (2007)As Queen Narissa | (Not seen) |
| movie | Mr. Woodcock (2007)As Beverly Farley | (Not seen) |
| tv | 30 Rock (2006)As Lynn Onkman(2 episodes) | (Not seen) |
| movie | Bernard and Doris (2006)As Doris Duke | (Not seen) |
| tv | The Tyra Banks Show (2005)(1 episode) | (Not seen) |
| movie | Romance & Cigarettes (2005)As Kitty Kane | (Not seen) |
| movie | Elizabethtown (2005)As Hollie Baylor | (Not seen) |
| tv | Project Runway (2004)As Self - Guest Judge(1 episode) | (Not seen) |
| movie | Shall We Dance? (2004)As Beverly Clark | (Not seen) |
| movie | Alfie (2004)As Liz | (Not seen) |
| tv | Chappelle's Show (2003)(1 episode) | (Not seen) |
| tv | Real Time with Bill Maher (2003)As Self(2 episodes) | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(3 episodes) | (Not seen) |
| movie | The Banger Sisters (2002)As Lavinia | (Not seen) |
| movie | Moonlight Mile (2002) (AKA "Baby's in Black")As Jojo Floss | (Not seen) |
| movie | Igby Goes Down (2002)As Mimi Slocumb | (Not seen) |
| movie | Cats & Dogs (2001)As Ivy (voice) | (Not seen) |
| tv | Malcolm in the Middle (2000)As Meg(2 episodes) | (Not seen) |
| movie | Rugrats in Paris (2000) (AKA "Rugrats in Paris: The Movie")As Coco LaBouche (voice) | (Not seen) |
| movie | Anywhere But Here (1999)As Adele August | (Not seen) |
| movie | Cradle Will Rock (1999)As Margherita Sarfatti | (Not seen) |
| movie | Stepmom (1998) (AKA "Good Night Moon")As Jackie Harrison | (Not seen) |
| movie | Twilight (1998) (AKA "The Magic Hour")As Catherine Ames | (Not seen) |
| tv | The Daily Show (1996)As Self(2 episodes) | (Not seen) |
| movie | James and the Giant Peach (1996)As Miss Spider (voice) | (Not seen) |
| movie | The Celluloid Closet (1995)As Self | (Not seen) |
| movie | Dead Man Walking (1995)As Sister Helen Prejean | (Not seen) |
| tv | Friends (1994)As Jessica Lockhart(1 episode) | (Not seen) |
| movie | Safe Passage (1994)As Margaret "Mag" Singer | (Not seen) |
| movie | Little Women (1994)As Mrs. Abigail "Marmee" March | (Not seen) |
| movie | The Client (1994)As Regina "Reggie" Love | (Not seen) |
| movie | Bob Roberts (1992)As Tawna Titan | (Not seen) |
| movie | Blast 'Em (1992) | (Not seen) |
| movie | Light Sleeper (1992)As Ann | (Not seen) |
| movie | Lorenzo's Oil (1992)As Michaela Odone | (Not seen) |
| movie | The Player (1992)As Susan Sarandon | (Not seen) |
| movie | Thelma & Louise (1991)As Louise Elizabeth Sawyer | (Not seen) |
| tv | The Simpsons (1989)As Susan Sarandon (voice)(2 episodes) | (Not seen) |
| movie | A Dry White Season (1989)As Melanie Bruwer | (Not seen) |
| movie | The January Man (1989)As Christine Starkey | (Not seen) |
| movie | Bull Durham (1988)As Annie Savoy | (Not seen) |
| movie | The Witches of Eastwick (1987)As Jane Spofford | (Not seen) |
| movie | The Hunger (1983)As Dr. Sarah Roberts | (Not seen) |
| movie | Atlantic City (1980) (AKA "Atlantic City, USA")As Sally | (Not seen) |
| movie | Pretty Baby (1978)As Hattie | (Not seen) |
| movie | The Great Smokey Roadblock (1977)As Ginny | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Cameo (uncredited)(3 episodes) | (Not seen) |
| movie | The Rocky Horror Picture Show (1975)As Janet Weiss | (Not seen) |
| movie | The Front Page (1974)As Peggy Grant | (Not seen) |
| tv | The Oscars (1953)As Self(7 episodes) | (Not seen) |