| tv | Number One on the Call Sheet (2025)As Self(1 episode) | (Not seen) |
| tv | Zero Day (2025)As President Evelyn Mitchell(6 episodes) | (Not seen) |
| movie | Mission: Impossible - The Final Reckoning (2025)As Erika Sloane | (Not seen) |
| movie | Damsel (2024)As Lady Bayford | (Not seen) |
| movie | Orion and the Dark (2024)As Sweet Dreams (voice) | (Not seen) |
| tv | Marvel's Moon Girl and Devil Dinosaur (2023)As Decoy (voice)(2 episodes) | (Not seen) |
| movie | Wendell & Wild (2022)As Sister Helley (voice) | (Not seen) |
| movie | Black Panther: Wakanda Forever (2022)As Ramonda | (Not seen) |
| tv | Marvel Studios Legends (2021)As Ramonda (archive footage) (uncredited)(2 episodes) | (Not seen) |
| tv | What If...? (2021)As Queen Ramonda (voice)(1 episode) | (Not seen) |
| movie | Gunpowder Milkshake (2021)As Anna May | (Not seen) |
| tv | 9-1-1: Lone Star (2020)As Sergeant Athena Grant(1 episode) | (Not seen) |
| movie | Soul (2020)As Dorothea (voice) | (Not seen) |
| tv | A Black Lady Sketch Show (2019)As Mo(1 episode) | (Not seen) |
| tv | The Imagineering Story (2019)As Narrator (voice)(6 episodes) | (Not seen) |
| movie | Avengers: Endgame (2019)As Ramonda | (Not seen) |
| tv | 9-1-1 (2018)As Athena Grant(142 episodes) | (Not seen) |
| movie | Bumblebee (2018)As Shatter (voice) | (Not seen) |
| movie | Mission: Impossible - Fallout (2018)As Erika Sloane | (Not seen) |
| movie | Black Panther (2018)As Ramonda | (Not seen) |
| movie | London Has Fallen (2016) (AKA "Olympus Has Fallen 2")As Lynne Jacobs | (Not seen) |
| tv | Master of None (2015)As Catherine(2 episodes) | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self - Guest(2 episodes) | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self(1 episode) | (Not seen) |
| movie | Survivor (2015)As Maureen Cranepaul | (Not seen) |
| tv | BoJack Horseman (2014)As Ana Spanakopita (voice)(10 episodes) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(3 episodes) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(1 episode) | (Not seen) |
| movie | White Bird in a Blizzard (2014)As Dr. Thaler | (Not seen) |
| movie | Black Nativity (2013)As Aretha Cobbs | (Not seen) |
| movie | Olympus Has Fallen (2013) (AKA "End of White House")As Lynne Jacobs | (Not seen) |
| tv | RuPaul's Drag Race All Stars (2012)As Self - Special Guest(1 episode) | (Not seen) |
| movie | This Means War (2012) (AKA "Black & White")As Collins | (Not seen) |
| tv | American Horror Story (2011)As Desiree Dupree(46 episodes) | (Not seen) |
| movie | Green Lantern (2011)As Dr. Amanda Waller | (Not seen) |
| movie | Notorious (2009)As Voletta Wallace | (Not seen) |
| movie | Nothing But the Truth (2008)As Bonnie Benjamin | (Not seen) |
| movie | Gospel Hill (2008)As Sarah Malcolm | (Not seen) |
| movie | Meet the Robinsons (2007) (AKA "A Day with Wilbur Robinson")As Mildred (voice) | (Not seen) |
| movie | Time Bomb (2006)As Jill Greco | (Not seen) |
| movie | Akeelah and the Bee (2006)As Tanya | (Not seen) |
| movie | Mr. & Mrs. Smith (2005) (AKA "Mr. and Mrs. Smith")As Mr. Smith's Boss (voice) (uncredited) | (Not seen) |
| movie | Mr. 3000 (2004)As Maureen "Mo" Simmons | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(1 episode) | (Not seen) |
| tv | Kath & Kim (2002)As Reesha | (Not seen) |
| movie | The Score (2001)As Diane | (Not seen) |
| movie | Supernova (2000)As Dr. Kaela Evers | (Not seen) |
| movie | Music of the Heart (1999)As Principal Janet Williams | (Not seen) |
| movie | Contact (1997)As Rachel Constantine | (Not seen) |
| movie | Strange Days (1995)As Lornette 'Mace' Mason | (Not seen) |
| movie | Vampire in Brooklyn (1995) (AKA "Wes Craven's Vampire In Brooklyn")As Detective Rita Veder | (Not seen) |
| tv | ER (1994)As Catherine Banfield(22 episodes) | (Not seen) |
| movie | What's Love Got to Do with It (1993)As Anna Mae Bullock / Tina Turner | (Not seen) |
| movie | Passion Fish (1992)As Rhonda / Dawn | (Not seen) |
| movie | Malcolm X (1992) (AKA "X")As Betty Shabazz | (Not seen) |
| movie | Critters 4 (1992) (AKA "Critters 4: They're Invading Your Space")As Fran | (Not seen) |
| movie | Innocent Blood (1992) (AKA "A French Vampire in America")As U.S. Attorney Sinclair | (Not seen) |
| movie | Boyz n the Hood (1991)As Reva Devereaux | (Not seen) |
| movie | Kindergarten Cop (1990)As Stewardess | (Not seen) |
| tv | The Simpsons (1989)As Michelle Obama (voice)(1 episode) | (Not seen) |
| movie | F/X (1986) (AKA "F/X - Murder by Illusion")As TV reporter | (Not seen) |
| tv | The Oscars (1953)As Self(6 episodes) | (Not seen) |