| movie | Scream 7 (2026)As Gale Weathers | (Not seen) |
| movie | Scream VI (2023)As Gale Weathers | (Not seen) |
| tv | Shining Vale (2022)As Patricia 'Pat' Phelps(16 episodes) | (Not seen) |
| movie | Scream (2022)As Gale Weathers | (Not seen) |
| movie | Friends: The Reunion (2021)As Self | (Not seen) |
| movie | You Cannot Kill David Arquette (2020)As Self | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self(1 episode) | (Not seen) |
| tv | Hot Ones (2015)As Self(1 episode) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(1 episode) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self(1 episode) | (Not seen) |
| tv | Go On (2012)As Talia(1 episode) | (Not seen) |
| tv | Shameless (2011)As Jen Wagner(1 episode) | (Not seen) |
| movie | Scream 4 (2011) (AKA "Scre4m")As Gale Weathers-Riley | (Not seen) |
| tv | Cougar Town (2009)As Jules Cobb(102 episodes) | (Not seen) |
| tv | Modern Family (2009)As Courteney Cox(1 episode) | (Not seen) |
| movie | Bedtime Stories (2008)As Wendy | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(1 episode) | (Not seen) |
| movie | Zoom (2006) (AKA "Zoom: Academy for Superheroes")As Marsha Holloway | (Not seen) |
| movie | The Tripper (2006)As Cynthia | (Not seen) |
| movie | Barnyard (2006) (AKA "Barnyard: The Original Party Animals")As Daisy the Cow (voice) | (Not seen) |
| movie | The Longest Yard (2005)As Lena (uncredited) | (Not seen) |
| movie | November (2004)As Sophie Jacobs | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(3 episodes) | (Not seen) |
| tv | Scrubs (2001)As Dr. Maddox(3 episodes) | (Not seen) |
| movie | 3000 Miles to Graceland (2001)As Cybil Waingrow | (Not seen) |
| movie | Scream 3 (2000) (AKA "Ghostface")As Gale Weathers | (Not seen) |
| movie | Scream 2 (1997) (AKA "Scream Again")As Gale Weathers | (Not seen) |
| movie | Scream (1996) (AKA "Scary Movie")As Gale Weathers | (Not seen) |
| tv | Friends (1994)As Monica Geller(228 episodes) | (Not seen) |
| movie | Ace Ventura: Pet Detective (1994)As Melissa Robinson | (Not seen) |
| tv | The Larry Sanders Show (1992)As Courteney Cox(1 episode) | (Not seen) |
| movie | Mr. Destiny (1990)As Jewel Jagger | (Not seen) |
| tv | Seinfeld (1989)As Meryl(1 episode) | (Not seen) |
| movie | Cocoon: The Return (1988) (AKA "Cocoon 2")As Sara | (Not seen) |
| movie | Masters of the Universe (1987) (AKA "Masters of the Universe: The Motion Picture")As Julie Winston | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Host(1 episode) | (Not seen) |