| movie | Marty Supreme (2025)As Carol Dunne | (Not seen) |
| movie | She Said (2022)As Self (voice) | (Not seen) |
| tv | American Horror Stories (2021)As Daphne (Voice)(1 episode) | (Not seen) |
| movie | WeWork: or The Making and Breaking of a $47 Billion Unicorn (2021) | (Not seen) |
| tv | Murder on Middle Beach (2020)As Sarah Orne Jewett (voice) | (Not seen) |
| movie | Avengers: Endgame (2019)As Pepper Potts | (Not seen) |
| movie | Avengers: Infinity War (2018)As Virginia "Pepper" Potts | (Not seen) |
| movie | Spider-Man: Homecoming (2017)As Virginia "Pepper" Potts | (Not seen) |
| tv | Chelsea (2016)As Self(1 episode) | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self - Guest(1 episode) | (Not seen) |
| tv | Hot Ones (2015)As Self - Guest(1 episode) | (Not seen) |
| movie | Mortdecai (2015)As Johanna Mortdecai | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(2 episodes) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self - Guest(2 episodes) | (Not seen) |
| movie | Marvel Studios: Assembling a Universe (2014)As Self | (Not seen) |
| movie | Iron Man 3 (2013)As Virginia "Pepper" Potts | (Not seen) |
| movie | Thanks for Sharing (2012)As Phoebe | (Not seen) |
| movie | The Avengers (2012) (AKA "Avengers Assemble")As Virginia "Pepper" Potts | (Not seen) |
| movie | Contagion (2011) (AKA "Contagion: The IMAX Experience")As Beth Emhoff | (Not seen) |
| movie | Iron Man 2 (2010) (AKA "Iron 2 Man")As Virginia "Pepper" Potts | (Not seen) |
| tv | Glee (2009)As Holly Holliday(5 episodes) | (Not seen) |
| tv | Shark Tank (2009)As Self - Shark(2 episodes) | (Not seen) |
| movie | Iron Man (2008) (AKA "Ironman")As Virginia "Pepper" Potts | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(3 episodes) | (Not seen) |
| movie | The Good Night (2007)As Dora Shaller | (Not seen) |
| movie | Running with Scissors (2006)As Hope Finch | (Not seen) |
| movie | Love and Other Disasters (2006)As Jacks | (Not seen) |
| movie | Proof (2005) (AKA "{proof}")As Catherine Llewellyn | (Not seen) |
| movie | Sky Captain and the World of Tomorrow (2004) (AKA "The World of Tomorrow")As Polly Perkins | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(3 episodes) | (Not seen) |
| movie | Sylvia (2003)As Sylvia Plath | (Not seen) |
| movie | View from the Top (2003) (AKA "Flight Girls")As Donna | (Not seen) |
| tv | American Idol (2002)As Self(1 episode) | (Not seen) |
| movie | Possession (2002)As Maud Bailey | (Not seen) |
| movie | Austin Powers in Goldmember (2002) (AKA "Austin Powers 3")As Dixie Normous | (Not seen) |
| movie | Shallow Hal (2001)As Rosemary Shanahan | (Not seen) |
| movie | Pootie Tang (2001) (AKA "Pootie Tang in Sine Your Pitty on the Runny Kine") | (Not seen) |
| movie | The Royal Tenenbaums (2001)As Margot Tenenbaum | (Not seen) |
| movie | Duets (2000)As Liv | (Not seen) |
| movie | The Talented Mr. Ripley (1999)As Marge Sherwood | (Not seen) |
| movie | Great Expectations (1998)As Estella | (Not seen) |
| movie | Hush (1998)As Helen Baring | (Not seen) |
| movie | Shakespeare in Love (1998)As Viola De Lesseps | (Not seen) |
| movie | Sliding Doors (1998)As Helen Quilley | (Not seen) |
| movie | A Perfect Murder (1998) (AKA "Dial M for Murder")As Emily Taylor | (Not seen) |
| tv | The Daily Show (1996)As Self(2 episodes) | (Not seen) |
| movie | Emma (1996)As Emma Woodhouse | (Not seen) |
| movie | Hard Eight (1996)As Clementine | (Not seen) |
| movie | Higher Learning (1995) | (Not seen) |
| movie | Se7en (1995) (AKA "Seven")As Tracy | (Not seen) |
| movie | Flesh and Bone (1993)As Ginnie | (Not seen) |
| movie | Malice (1993) (AKA "Bodily Harm")As Paula Bell | (Not seen) |
| movie | Hook (1991)As Young Wendy | (Not seen) |
| tv | Saturday Night Live (1975)As Self - Host(6 episodes) | (Not seen) |
| tv | The Oscars (1953)As Self(5 episodes) | (Not seen) |