| movie | They Will Kill You (2026) | (Not seen) |
| tv | Hot Ones Versus (2024)As Self(1 episode) | (Not seen) |
| tv | High Desert (2023)As Peggy Newman(8 episodes) | (Not seen) |
| tv | Severance (2022)As Harmony Cobel(19 episodes) | (Not seen) |
| movie | You Cannot Kill David Arquette (2020)As Self | (Not seen) |
| tv | The Act (2019)As Dee Dee Blanchard(8 episodes) | (Not seen) |
| movie | Toy Story 4 (2019)As Harmony’s Mom (voice) | (Not seen) |
| tv | Escape at Dannemora (2018)As Joyce 'Tilly' Mitchell(7 episodes) | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self(1 episode) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(1 episode) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(2 episodes) | (Not seen) |
| movie | Boyhood (2014)As Mom | (Not seen) |
| movie | A Glimpse Inside the Mind of Charles Swan III (2012)As Izzy | (Not seen) |
| tv | Boardwalk Empire (2010)As Sally Wheet(10 episodes) | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(2 episodes) | (Not seen) |
| movie | Holes (2003)As Katherine "Kissin' Kate" Barlow | (Not seen) |
| movie | Tiptoes (2002)As Lucy | (Not seen) |
| movie | The Badge (2002)As Scarlett | (Not seen) |
| movie | Human Nature (2001)As Lila Jute | (Not seen) |
| movie | Little Nicky (2000)As Valerie Veran | (Not seen) |
| tv | Law & Order: Special Victims Unit (1999)As Jeannie Kerns(1 episode) | (Not seen) |
| movie | Bringing Out the Dead (1999)As Mary Burke | (Not seen) |
| movie | Stigmata (1999) (AKA "Toby's Story")As Frankie Paige | (Not seen) |
| movie | Goodbye Lover (1998) (AKA "Patricia Arquette's Goodbye Lover")As Sandra Dunmore | (Not seen) |
| movie | Pretty as a Picture: The Art of David Lynch (1997)As Self | (Not seen) |
| movie | Nightwatch (1997)As Katherine | (Not seen) |
| movie | Lost Highway (1997)As Renee Madison / Alice Wakefield | (Not seen) |
| movie | The Secret Agent (1996)As Winnie | (Not seen) |
| movie | Flirting with Disaster (1996)As Nancy Coplin | (Not seen) |
| movie | Ed Wood (1994)As Kathy O'Hara | (Not seen) |
| movie | True Romance (1993) (AKA "Breakaway")As Alabama Whitman | (Not seen) |
| movie | The Indian Runner (1991) (AKA "Indian Runner")As Dorothy | (Not seen) |
| movie | Uncle Buck (1989)As Additional Voices (voice) | (Not seen) |
| movie | A Nightmare on Elm Street 3: Dream Warriors (1987) (AKA "A Nightmare on Elm Street Part III")As Kristen Parker | (Not seen) |