| You Cannot Kill David Arquette (2020)As Self | (Not seen) |
| Toy Story 4 (2019)As Harmony’s Mom (voice) | (Not seen) |
| Boyhood (2014)As Mom | (Not seen) |
| A Glimpse Inside the Mind of Charles Swan III (2012)As Izzy | (Not seen) |
| Holes (2003)As Katherine "Kissin' Kate" Barlow | (Not seen) |
| Tiptoes (2002)As Lucy | (Not seen) |
| The Badge (2002)As Scarlett | (Not seen) |
| Human Nature (2001)As Lila Jute | (Not seen) |
| Little Nicky (2000)As Valerie Veran | (Not seen) |
| Bringing Out the Dead (1999)As Mary Burke | (Not seen) |
| Stigmata (1999) (AKA "Toby's Story")As Frankie Paige | (Not seen) |
| Goodbye Lover (1998) (AKA "Patricia Arquette's Goodbye Lover")As Sandra Dunmore | (Not seen) |
| Pretty as a Picture: The Art of David Lynch (1997)As Self | (Not seen) |
| Nightwatch (1997)As Katherine | (Not seen) |
| Lost Highway (1997)As Renee Madison / Alice Wakefield | (Not seen) |
| The Secret Agent (1996)As Winnie | (Not seen) |
| Flirting with Disaster (1996)As Nancy Coplin | (Not seen) |
| Ed Wood (1994)As Kathy O'Hara | (Not seen) |
| True Romance (1993) (AKA "Breakaway")As Alabama Whitman | (Not seen) |
| The Indian Runner (1991) (AKA "Indian Runner")As Dorothy | (Not seen) |
| Uncle Buck (1989)As Additional Voices (voice) | (Not seen) |
| A Nightmare on Elm Street 3: Dream Warriors (1987) (AKA "A Nightmare on Elm Street Part III")As Kristen Parker | (Not seen) |