| movie | "Famous Last Words" Eric Dane (2026) (AKA "Famous Last Words: Eric Dane")As Self | (Not seen) |
| tv | Countdown (2025)As Nathan Blythe(13 episodes) | (Not seen) |
| movie | Borderline (2025)As Bell | (Not seen) |
| tv | Brilliant Minds (2024)As Matthew Ramati(1 episode) | (Not seen) |
| movie | One Fast Move (2024)As Dean Miller | (Not seen) |
| movie | Bad Boys: Ride or Die (2024)As McGrath | (Not seen) |
| movie | Little Dixie (2023)As Governor Richard Jeffs | (Not seen) |
| movie | Americana (2023)As Dillon Macintosh | (Not seen) |
| tv | Euphoria (2019)As Cal Jacobs(24 episodes) | (Not seen) |
| movie | Grey Lady (2017)As Doyle | (Not seen) |
| tv | The Last Ship (2014)As CO CDR Tom Chandler(56 episodes) | (Not seen) |
| movie | Burlesque (2010)As Marcus Gerber | (Not seen) |
| movie | Valentine's Day (2010)As Sean Jackson | (Not seen) |
| movie | Marley & Me (2008) (AKA "Marley and Me")As Sebastian Tunney | (Not seen) |
| movie | Open Water 2: Adrift (2006) (AKA "Adrift")As Dan | (Not seen) |
| movie | X-Men: The Last Stand (2006) (AKA "X-Men 3")As Multiple Man | (Not seen) |
| tv | Grey's Anatomy (2005)As Mark Sloan(140 episodes) | (Not seen) |
| movie | Painkiller Jane (2005)As Nick | (Not seen) |
| movie | Feast (2005)As Hero | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(2 episodes) | (Not seen) |
| tv | Family Guy (1999)As Eric Dane (voice)(1 episode) | (Not seen) |
| tv | Charmed (1998)As Jason Dean(9 episodes) | (Not seen) |
| movie | Serving in Silence: The Margarethe Cammermeyer Story (1995) (AKA "Serving in Silence")As Matt | (Not seen) |
| tv | The Wonder Years (1988)As Brett(1 episode) | (Not seen) |
| tv | Married... with Children (1987)As Oliver Cole(1 episode) | (Not seen) |