| tv | Number One on the Call Sheet (2025)As Self(1 episode) | (Not seen) |
| movie | G20 (2025)As Danielle Sutton | (Not seen) |
| tv | Hot Ones Versus (2024)As Self(1 episode) | (Not seen) |
| tv | Creature Commandos (2024)As Amanda Waller (voice)(4 episodes) | (Not seen) |
| movie | Kung Fu Panda 4 (2024)As Chameleon (voice) | (Not seen) |
| movie | Air (2023) (AKA "Air: Courting a Legend")As Deloris Jordan | (Not seen) |
| movie | The Hunger Games: The Ballad of Songbirds & Snakes (2023)As Dr. Volumnia Gaul | (Not seen) |
| tv | Peacemaker (2022)As Amanda Waller (uncredited)(2 episodes) | (Not seen) |
| movie | The Woman King (2022)As Nanisca | (Not seen) |
| movie | Black Adam (2022)As Amanda Waller (uncredited) | (Not seen) |
| movie | The Unforgivable (2021)As Liz Ingram | (Not seen) |
| movie | The Suicide Squad (2021)As Amanda Waller | (Not seen) |
| movie | Ma Rainey's Black Bottom (2020)As Ma Rainey | (Not seen) |
| movie | Widows (2018)As Veronica | (Not seen) |
| movie | Bright Lights: Starring Carrie Fisher and Debbie Reynolds (2016) | (Not seen) |
| movie | Fences (2016)As Rose Maxson | (Not seen) |
| movie | Suicide Squad (2016) (AKA "Task Force X")As Amanda Waller | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self(2 episodes) | (Not seen) |
| tv | Hot Ones (2015)As Self(1 episode) | (Not seen) |
| movie | Lila & Eve (2015)As Lila | (Not seen) |
| movie | Blackhat (2015)As Carol Barrett | (Not seen) |
| tv | How to Get Away with Murder (2014)As Annalise Keating(90 episodes) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self(3 episodes) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(4 episodes) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self - Guest(1 episode) | (Not seen) |
| movie | Beautiful Creatures (2013)As Amma Treadeau | (Not seen) |
| movie | Ender's Game (2013)As Major Gwen Anderson | (Not seen) |
| movie | Prisoners (2013)As Nancy Birch | (Not seen) |
| tv | Scandal (2012)As Annalise Keating(1 episode) | (Not seen) |
| movie | Extremely Loud & Incredibly Close (2011)As Abby Black | (Not seen) |
| movie | The Help (2011)As Aibileen Clark | (Not seen) |
| movie | Trust (2010)As Gail Friedman | (Not seen) |
| movie | It's Kind of a Funny Story (2010)As Dr. Eden Minerva | (Not seen) |
| movie | Knight and Day (2010) (AKA "Knight & Day")As CIA Director Isabel George | (Not seen) |
| movie | Madea Goes to Jail (2009) (AKA "Tyler Perry's Madea Goes to Jail")As Ellen | (Not seen) |
| movie | Law Abiding Citizen (2009)As Mayor April Henry | (Not seen) |
| movie | State of Play (2009)As Dr. Judith Franklin | (Not seen) |
| movie | Doubt (2008)As Mrs. Miller | (Not seen) |
| tv | The Andromeda Strain (2008)As Dr. Charlene Barton(2 episodes) | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(1 episode) | (Not seen) |
| movie | Disturbia (2007)As Detective Parker | (Not seen) |
| movie | The Architect (2006)As Tonya Neely | (Not seen) |
| movie | World Trade Center (2006) (AKA "September")As Mother in Hospital with Donna | (Not seen) |
| movie | Get Rich or Die Tryin' (2005)As Grandma | (Not seen) |
| movie | Syriana (2005) (AKA "See No Evil")As CIA Chairwoman | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(1 episode) | (Not seen) |
| movie | Antwone Fisher (2002)As Eva May | (Not seen) |
| movie | Far from Heaven (2002) (AKA "Loin du paradis")As Sybil | (Not seen) |
| movie | Solaris (2002)As Gordon | (Not seen) |
| movie | Kate & Leopold (2001) (AKA "Kate and Leopold")As Policewoman | (Not seen) |
| movie | Ocean's Eleven (2001) (AKA "11")As Parole Board Interrogator (voice) (uncredited) | (Not seen) |
| movie | Traffic (2000)As Social Worker | (Not seen) |
| tv | Law & Order: Special Victims Unit (1999)As Donna Emmett(7 episodes) | (Not seen) |
| movie | The Pentagon Wars (1998)As Platoon Sgt. Fanning | (Not seen) |
| movie | Out of Sight (1998)As Moselle | (Not seen) |
| tv | The Practice (1997)As Aisha Crenshaw(1 episode) | (Not seen) |
| tv | The Simpsons (1989)As Narrator (voice)(1 episode) | (Not seen) |
| tv | The Oscars (1953)As Self(1 episode) | (Not seen) |