| movie | Is This Thing On? (2025)As Tess Novak | (Not seen) |
| movie | Caught Stealing (2025)As Hank's Mom | (Not seen) |
| movie | Jay Kelly (2025)As Liz | (Not seen) |
| movie | SNL50: The Homecoming Concert (2025) | (Not seen) |
| movie | Lonely Planet (2024)As Katherine Loewe | (Not seen) |
| movie | The Son (2022)As Kate | (Not seen) |
| movie | Halftime (2022) (AKA "Jennifer Lopez: Halftime")As Self | (Not seen) |
| movie | Jurassic World: Dominion (2022) (AKA "Jurassic World Dominion")As Dr. Ellie Sattler | (Not seen) |
| tv | The White Lotus (2021)As Abby (voice)(1 episode) | (Not seen) |
| movie | Crazy, Not Insane (2020)As Literary Voice of Dorothy Lewis (voice) | (Not seen) |
| movie | Little Women (2019)As Margaret "Marmee" March | (Not seen) |
| movie | Marriage Story (2019)As Nora Fanshaw | (Not seen) |
| movie | Cold Pursuit (2019)As Grace Coxman | (Not seen) |
| movie | Ellen DeGeneres: Relatable (2018) | (Not seen) |
| movie | Trial by Fire (2018)As Elizabeth Gilbert | (Not seen) |
| tv | Big Little Lies (2017)As Renata Klein(14 episodes) | (Not seen) |
| movie | Spielberg (2017)As Self | (Not seen) |
| movie | Downsizing (2017)As Laura Lonowski | (Not seen) |
| movie | Star Wars: Episode VIII - The Last Jedi (2017) (AKA "Star Wars: The Last Jedi")As Vice Admiral Amilyn Holdo | (Not seen) |
| movie | The Founder (2016)As Ethel Kroc | (Not seen) |
| movie | Certain Women (2016)As Laura Wells | (Not seen) |
| tv | F is for Family (2015)As Sue Murphy (voice)(44 episodes) | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self(1 episode) | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self - Guest(1 episode) | (Not seen) |
| tv | Unbreakable Kimmy Schmidt (2015)As Wendy Hebert(1 episode) | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self - Guest(1 episode) | (Not seen) |
| tv | Variety Studio: Actors on Actors (2014)As Self(4 episodes) | (Not seen) |
| tv | Late Night with Seth Meyers (2014)As Self(2 episodes) | (Not seen) |
| movie | 99 Homes (2014)As Lynn Nash | (Not seen) |
| movie | Wild (2014)As Bobbi Grey | (Not seen) |
| movie | The Fault in Our Stars (2014) (AKA "TFiOS")As Frannie Lancaster | (Not seen) |
| tv | The Mindy Project (2012)As Dr. Ludmilla Trapezikov(1 episode) | (Not seen) |
| movie | The Master (2012)As Helen | (Not seen) |
| movie | Beastie Boys: Fight for Your Right Revisited (2011) (AKA "Fight for Your Right Revisited")As Cafe Patron | (Not seen) |
| movie | Everything Must Go (2010)As Delilah | (Not seen) |
| movie | Little Fockers (2010)As Prudence | (Not seen) |
| movie | Tenderness (2009)As Teresa | (Not seen) |
| movie | Recount (2008)As Katherine Harris | (Not seen) |
| movie | More Things That Happened (2007)As Susan Blue | (Not seen) |
| movie | Lynch (2007) (AKA "Lynch (one)")As Self | (Not seen) |
| movie | Inland Empire (2006) (AKA "Inland Empire: A Woman in Trouble")As Nikki Grace / Susan Blue | (Not seen) |
| movie | Lonely Hearts (2006) (AKA "Lonely Hearts Killers")As Rene | (Not seen) |
| movie | Happy Endings (2005)As Pam | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(3 episodes) | (Not seen) |
| movie | Novocaine (2001)As Jean Noble | (Not seen) |
| movie | Jurassic Park III (2001) (AKA "JP3")As Dr. Ellie Sattler | (Not seen) |
| movie | I Am Sam (2001)As Randy Carpenter | (Not seen) |
| movie | Dr. T & the Women (2000)As Peggy | (Not seen) |
| tv | The West Wing (1999)As Tabatha Fortis(1 episode) | (Not seen) |
| movie | October Sky (1999)As Miss Riley | (Not seen) |
| tv | King of the Hill (1997)As Katherine (voice)(2 episodes) | (Not seen) |
| movie | Citizen Ruth (1996) (AKA "Precious")As Ruth Stoops | (Not seen) |
| tv | Frasier (1993)As June (voice)(1 episode) | (Not seen) |
| movie | A Perfect World (1993)As Sally Gerber | (Not seen) |
| movie | Jurassic Park (1993) (AKA "JP")As Dr. Ellie Sattler | (Not seen) |
| tv | The Larry Sanders Show (1992)As Laura Dern(1 episode) | (Not seen) |
| tv | Twin Peaks (1990)As Diane Evans(9 episodes) | (Not seen) |
| movie | Industrial Symphony No. 1: The Dream of the Brokenhearted (1990)As Heartbroken Woman | (Not seen) |
| movie | Wild at Heart (1990) (AKA "David Lynch's Wild at Heart")As Lula Fortune | (Not seen) |
| movie | Fat Man and Little Boy (1989)As Kathleen Robinson | (Not seen) |
| movie | Haunted Summer (1988)As Claire Clairmont | (Not seen) |
| movie | Blue Velvet (1986)As Sandy Williams | (Not seen) |
| movie | Mask (1985) (AKA "Peter Bogdanovich's Mask")As Diana Adams | (Not seen) |
| movie | Teachers (1984)As Diane | (Not seen) |
| movie | Ladies and Gentlemen, the Fabulous Stains (1982)As Jessica McNeil | (Not seen) |
| tv | Saturday Night Live (1975)As Self (uncredited)(1 episode) | (Not seen) |
| movie | Alice Doesn't Live Here Anymore (1974)As Girl Eating Ice Cream Cone (uncredited) | (Not seen) |
| movie | White Lightning (1973)As Sharon Ann, Maggie's daughter | (Not seen) |
| tv | The Oscars (1953)As Self(4 episodes) | (Not seen) |