| movie | Netflix Tudum 2025 (2025)As Self | (Not seen) |
| movie | Wake Up Dead Man: A Knives Out Mystery (2025)As Chief Geraldine Scott | (Not seen) |
| movie | Goodrich (2024)As Grace | (Not seen) |
| tv | That '90s Show (2023)As Jackie Burkhart(1 episode) | (Not seen) |
| movie | Luckiest Girl Alive (2022)As Ani FaNelli | (Not seen) |
| movie | Breaking News in Yuba County (2021)As Nancy | (Not seen) |
| movie | Four Good Days (2020)As Molly | (Not seen) |
| tv | The Boys (2019)As Mila Kunis (uncredited)(1 episode) | (Not seen) |
| movie | The Spy Who Dumped Me (2018)As Audrey | (Not seen) |
| movie | A Bad Moms Christmas (2017)As Amy Mitchell | (Not seen) |
| movie | Bad Moms (2016)As Amy Mitchell | (Not seen) |
| tv | The Late Late Show with James Corden (2015)As Self(3 episodes) | (Not seen) |
| tv | The Late Show with Stephen Colbert (2015)As Self(1 episode) | (Not seen) |
| tv | Hot Ones (2015)As Self(1 episode) | (Not seen) |
| movie | Jupiter Ascending (2015)As Jupiter Jones | (Not seen) |
| tv | The Tonight Show Starring Jimmy Fallon (2014)As Self - Guest(2 episodes) | (Not seen) |
| movie | Annie (2014)As Andrea Alvin | (Not seen) |
| movie | The Angriest Man in Brooklyn (2014)As Dr. Sharon Gill | (Not seen) |
| movie | Third Person (2013)As Julia | (Not seen) |
| movie | Blood Ties (2013)As Natalie | (Not seen) |
| movie | Oz the Great and Powerful (2013)As Theodora | (Not seen) |
| movie | Ted (2012)As Lori Collins | (Not seen) |
| movie | "Family Guy" It's a Trap! (2011) (AKA "Family Guy Presents: It's a Trap!")As Meg Griffin (voice) | (Not seen) |
| movie | Friends with Benefits (2011) (AKA "Stay Friends")As Jamie Rellis | (Not seen) |
| movie | Black Swan (2010)As Lily | (Not seen) |
| movie | The Book of Eli (2010) (AKA "The Walker")As Solara | (Not seen) |
| movie | Date Night (2010)As Whippit | (Not seen) |
| tv | The Cleveland Show (2009)(1 episode) | (Not seen) |
| movie | "Family Guy" Something, Something, Something, Dark Side (2009) (AKA "Family Guy Presents: Something, Something, Something, Dark Side")As Meg Griffin as Giant Space Slug (voice) | (Not seen) |
| movie | Extract (2009)As Cindy | (Not seen) |
| movie | Boot Camp (2008)As Sophie | (Not seen) |
| movie | Forgetting Sarah Marshall (2008)As Rachel Jansen | (Not seen) |
| movie | Max Payne (2008)As Mona Sax | (Not seen) |
| tv | The Graham Norton Show (2007)As Self(1 episode) | (Not seen) |
| movie | "Family Guy" Blue Harvest (2007) (AKA "Family Guy Presents: Blue Harvest")As Meg Griffin (voice) | (Not seen) |
| movie | Moving McAllister (2007)As Michelle McAllister | (Not seen) |
| movie | After Sex (2007)As Nikki | (Not seen) |
| movie | The Hills with James Franco and Mila Kunis (2007)As Audrina | (Not seen) |
| tv | Robot Chicken (2005)(1 episode) | (Not seen) |
| movie | Stewie Griffin: The Untold Story (2005) (AKA "Family Guy: The Movie")As Meg Griffin / Additional Voices (voice) | (Not seen) |
| tv | Two and a Half Men (2003)As Vivian(1 episode) | (Not seen) |
| tv | The Ellen DeGeneres Show (2003)As Self(1 episode) | (Not seen) |
| movie | American Psycho II: All American Girl (2002) (AKA "American Psycho 2")As Rachael Newman | (Not seen) |
| tv | Curb Your Enthusiasm (2000)As Mila Kunis(1 episode) | (Not seen) |
| tv | Family Guy (1999)As Meg Griffin (voice)(448 episodes) | (Not seen) |
| tv | That '70s Show (1998)As Jackie Burkhart(200 episodes) | (Not seen) |
| movie | Gia (1998)As Gia Carangi (age 11) | (Not seen) |
| movie | Honey, We Shrunk Ourselves! (1997) (AKA "Honey, We Shrunk Ourselves")As Jill | (Not seen) |
| movie | Santa with Muscles (1996)As Sarah | (Not seen) |
| movie | Piranha (1995)As Susie Grogan | (Not seen) |
| tv | Baywatch (1989)(2 episodes) | (Not seen) |
| tv | The Oscars (1953)As Self(1 episode) | (Not seen) |